Hypoparathyroidism (hypoPT) is characterized by low levels of PTH. In this study we will test the effects of a liquid meal on the bone remodeling in participants with hypoparathyroidism. Furthermore, we will test the effects of the gut hormones GIP and GLP-2.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
7
Hvidovre University Hospital
Hvidovre, Denmark
Serum concentration of C-terminal telopeptide (CTX)
Marker of bone resorption, measured in serum
Time frame: -10 to 240 minutes
N-terminal propeptide of type 1 procollagen (P1NP)
Marker of bone formation, concentration measured in serum
Time frame: -10 to 240 minutes
PTH
PTH concentration measured in serum
Time frame: -10 to 240 minutes
Glucose-dependent insulinotropic polypeptide (GIP)
Gut hormone, concentration measured in plasma
Time frame: -10 to 240 minutes
Glucagon-like peptide-2 (GLP-2)
Gut hormone, concentration measured in plasma
Time frame: -10 to 240 minutes
Glucagon-like peptide-1 (GLP-1)
Gut hormone, concentration measured in plasma
Time frame: -10 to 240 minutes
Glucose
Glucose concentration measured in serum
Time frame: -10 to 240 minutes
Insulin
Insulin concentration measured in serum
Time frame: -10 to 240 minutes
C-peptide
C-peptide concentration measured in serum
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Subcutaneous injected Placebo (saline)
Time frame: -10 to 240 minutes