To study immunological tolerance effect after frequent rabies booster vaccination
Previous studies had shown lower antibody titers among those who received frequent rabies booster vaccination, compared to ones who had got primary immunization. We study immunological cells i.e., regulatory T cell, regulatory B cell, T follicular helper cell, and cytokines in those who received frequent rabies booster vaccination.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
All participants would be given one dose of rabies vaccine and monitor the immunological cells i.e., regulatory T cell, regulatory B cell, T follicular helper cells, cytokines i.e., IL-10, TGF-Beta, and Rabies neutralizing antibody titers, before and after the booster injection
Queen Saovabha Memorial Institute
Pathum Wan, Bangkok, Thailand
RECRUITINGRabies specific regulatory T cells
Rabies specific regulatory T cells are measured by flow cytometry method
Time frame: Change from baseline of numbers of Rabies specific regulatory T cells before (baseline) and one month after receipt of rabies booster vaccination were compared between 2 arms
Rabies specific regulatory B cells
Rabies specific regulatory B cells are measured by flow cytometry method
Time frame: Change from baseline of numbers of Rabies specific regulatory B cells before (baseline) and one month after receipt of rabies booster vaccination were compared between 2 arms
Rabies specific T follicular helper cells
Rabies specific T follicular helper cells are measured by flow cytometry method
Time frame: Change from baseline of numbers of Rabies specific T follicular helper cells before (baseline) and one month after receipt of rabies booster vaccination were compared between 2 arms
Rabies Neutralizing Antibody Titers (RNab)
Rabies Neutralizing Antibody Titers would be represented and compared by geometric mean titers (GMTs)
Time frame: before (baseline) and one month after receipt of rabies booster vaccination
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