Microcirculation in Patients With Leukemic Hyperleukocytosis

University Hospital Muenster29 enrolled

Overview

Hyperleukocytosis in patients with acute leukemia impacts rheology and microvascularization, leading to severe symptoms or even death. The investigators investigated whether blood stream alterations induced by hyperleukocytosis can be detected by sidestream dark-field imaging and whether they correlate with the grade of symptoms.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Hyperleukocytic Syndrome

Interventions

intravital microscopyDIAGNOSTIC_TEST

intravital microscopy with sidestream dark-field imaging

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * acute leukemia * de-novo or relapsed stage * able to give consent Exclusion Criteria: * severe oral mucositis * unable to give consent * pregnant women * patients hospitalized for psychiatric disease

Locations (1)

Universitätsklinikum Münster

Münster, Germany

Outcomes

Primary Outcomes

microvascular flow index (MFI) of sublingual microcirculation

Time frame: 24 months

Data from ClinicalTrials.gov

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