Exogenous Oxidation of Fructose-glucose Mixtures During Running

University of Bath9 enrolled

Overview

The aim of this study is to characterise exogenous carbohydrate oxidation rates during exercise, when ingesting glucose (polymers) only, compared to glucose-fructose mixtures, and glucose-fructose mixtures ingested in hydrogel form.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Exercise

Interventions

Fructose-maltodextrinDIETARY_SUPPLEMENT

Fructose plus maltodextrin in a ratio of 1:1.4, diluted in water to produce a 16% carbohydrate solution.

Fructose-maltodextrin hydrogelDIETARY_SUPPLEMENT

Fructose plus maltodextrin in a ratio of 1:1.4, encapsulated in an alginate-pectin hydrogel diluted in water to produce a 16% carbohydrate solution.

Glucose-maltodextrinDIETARY_SUPPLEMENT

Glucose plus maltodextrin in a ratio of 1:1.4, diluted in water to produce a 16% carbohydrate solution.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Maximal oxygen consumption \> 50 ml.kg-1.min-1 * \> 1 year training in endurance running or triathlon * No current injury or injury within the last three months * No history of cardiac or metabolic disease such as coronary heart disease or diabetes * No current or history of gastrointestinal issues * Successful completion of the physical activity readiness questionnaire (PAR-Q) Exclusion Criteria: * Female * Untrained in endurance running * Current injury or injury within the past three months * History of cardiac or metabolic disease such as coronary heart disease or diabetes * History of or current gastrointestinal issues such as irritable bowel syndrome * Unable to replicate diet and training for 3 and 5 days respectively prior to each experimental visit.

Locations (1)

Department for Health, University of Bath

Bath, United Kingdom

Outcomes

Primary Outcomes

Peak exogenous carbohydrate oxidation rate

Peak exogenous carbohydrate oxidation rate during 120 min of treadmill running. Measured using isotope ratio mass spectrometry and reported in grams per minute

Time frame: 120 minutes

Secondary Outcomes

Total carbohydrate oxidation

Total carbohydrate oxidation during 120 min of treadmill running. Measured using indirect calorimetry and reported in grams.

Time frame: 120 minutes

Ratings of gastrointestinal discomfort

Subjective ratings of gastrointestinal discomfort during 120 min of treadmill running. Measured using a 9-item questionnaire on a scale of 1 to 7, where 1 = No discomfort at all and 7 = very severe discomfort. Items: Stomach; Heartburn; Acid reflux; Nausea; Rumbling; Bloated; Burping; Passing gas; Bowel movement.

Time frame: 120 minutes

Total fat oxidation

Total fat oxidation during 120 min of treadmill running. Measured using indirect calorimetry and reported in grams.

Time frame: 120 minutes

Plasma insulin concentrations

Plasma insulin concentrations during 120 min of treadmill running. Measured using enzyme-linked immunosorbent assay and reported in pmol/L.

Time frame: 120 minutes

Plasma glucose concentrations

Plasma lactate concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in mmol/L.

Time frame: 120 minutes

Plasma lactate concentrations

Plasma lactate concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in mmol/L.

Data from ClinicalTrials.gov

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