Remineralization Potential of MI Varnish Versus Fluoride Varnish on White Spot Lesions in Maxillary Primary Incisors

Cairo University60 enrolled

Overview

Remineralization effect of CPP-ACP and Fluoride (MI varnish) versus Fluoride varnish on white spot lesions in maxillary primary incisors

Early childhood caries (ECC) is a very common and consequential chronic disease affecting young children ( Çolak et al., 2013). The prevalence of ECC in Egypt is high, it is about (78%) according to the last Egyptian Report, 2014. ECC begins with white-spot lesions, and caries can progress continuously, leading to complete destruction of the crown. Calcium and phosphate ions are more readily lost for children because lower mineralization of deciduous enamel. The disease usually develops very quickly and causes many childhood health problems, such as caries-related toothache and infection. Demineralization and remineralization are dynamic processes in caries initiation, progression, and reversal. Therefore, regulation of the demineralization- remineralization balance is a key to caries prevention and treatment. The ideal method of increasing remineralization is reconstructing the depleted tissues with hydroxyapatite, which is the same inorganic component as the enamel. Fluoride varnishes have been the standard practice for the professional application of fluoride. Casien PhosphoPeptide (CPP) is a sticky protein that binds and stabilizes calcium and phosphate ions in an amorphous state. CPP-ACP has been shown to adhere to teeth surfaces.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Remineralization Effect of the Varnish on White Spot Lesions

Interventions

MI varnishOTHER

CPP- ACP with 5 % sodium fluoride GC

Eligibility

Sex: ALLMin age: 3 YearsMax age: 5 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Children with white spot lesions on their incisors. 2. Age ranging 3-5 years. 3. Good general health. Exclusion Criteria: 1\. Chronic use of medications or antibiotics 2. lack of cooperation in the oral examination 3. Allergies to milk protein or benzoate preservatives 4. Presence of oral soft-tissue lesions or enamel hypoplasia at baseline examination, 5. Children who have received a fluoride supplement or professional topical fluoride application at least 3 months before or during the study period. \-

Locations (1)

Faculty of Dentistry- Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

Caries activity

Measured by ICDAS II

Time frame: Change from base line, after application at 3, 6, 9 last follow up 12 months

Secondary Outcomes

Remineralization

Measured by EDI

Time frame: Change from base line, after application at 3, 6, 9 last follow up 12 months

Data from ClinicalTrials.gov

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