To investigate the effect of delayed cord clamping (DCC) on hematopoietic progenitor cells (HPCs), hematological parameters including haemoglobin concentration and hematocrit value in premature infants (34 weeks gestational age or less) with placental insufficiency.We hypothesized that preterm infants with placental insufficiency underwent DDC could have better hematologic parameters and hematopoietic progenitor cells compared to immediate cord clamping.
• A prospective randomized controlled study will be performed on preterm infants 34 weeks gestational age or less with placental insufficiency, and those without placental insufficiency where DCC will be performed in both groups. A third group of preterm with placental insufficiency and immediate cord clamping will be performed as a control.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
90
Cord clamping 60 seconds after delivery of fetus in preterm infants
Mansoura University Children's Hospital
Al Mansurah, Egypt
Peripheral venous CD34 at admission
One milliliter of fetal blood will be taken from peripheral venous blood in the first 30 minutes of life and CD34 will be assessed by flow cytometry.
Time frame: first 24 hours of infants' life
Admission hemoglobin
One milliliter of neonatal blood will be taken from peripheral venous blood in the first 24 hours of life.
Time frame: first 24 hours of infants' life
Hemoglobin at 2 months
One milliliter of neonatal blood will be taken from peripheral venous blood at 2 months of life.
Time frame: 2 months of infants' life
Admission platelets
One milliliter of neonatal blood will be taken from peripheral venous blood in the first 24 hours of life.
Time frame: first 24 hours of infants' life
Admission WBCs
One milliliter of neonatal blood will be taken from peripheral venous blood in the first 24
Time frame: first 24 hours of infants' life
Phototherapy requirements
Time frame: first 28 days of life
Polycythemia
Time frame: first 28 days of life
Culture proven sepsis
Time frame: first 28 days of life
Necrotizing enterocolitis
Time frame: first 28 days of life
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Intraventricular hemorrhage
Time frame: first 28 days of life
Bronchopulmonary dysplasia
Time frame: first 70 days of life
Need for nasal CPAP
Time frame: first 28 days of life
Need for mechanical ventilation
Time frame: first 28 days of life
Duration of oxygen therapy
Time frame: first 28 days of life
Need for inotropes
Time frame: first 28 days of life
Retinopathy of prematurity
Time frame: first 28 days of life
Need for packed RBCs transfusion
Time frame: first 28 days of life