The use of massage chairs is becoming more popular in many countries. According to the previous reports, some manual massages have positive effects on the mood, pain, fatigue, and sleep quality. However, the clinical benefits of the massage chair have not been fully understood. In this trial, it is aimed to evaluate the clinical effectiveness of the 6-month regular use of massage chair twice a day. It is hypothesized that long-term regular use of massage chair has positive effects on the hormonal level related to the stress, inflammation, and aging, as well as physical, psychologic, and muscle quality.
A total of enrolled 80 patients after randomization(1:1) in intervention(Massage chair)group and Control groups, will be provided * Massage chair group * lifestyle modification education + using massage chair twice per day during 24weeks * control group: only lifestyle modification education 1. Screening visit * collection demographic data, BMD, vital sign, Medication history 2. Visit 1 (0-week) 1. Vital sign 2. Charlson comorbidity index 3. Laboratory test * WBC diff count, Hb, creatinine, ALT, albumin, hsCRP, ESR cortisol, serotonin, DHEA-s, IGF-1, NK cell, Telomere length 4. Questionnaire: K-MMSE, SGDS-K, BEPSI-K, EQ-5D-5L 5. Physical\& muscular assessment * SPPB, Grip strength, Muscle tone, Bioimpedance analysis 3. Visit 2-6 (4,8,12,16 weeks) via Phone contact: assess compliance and adverse events 4. visit 7 (24weeks) 1. Vital sign 2. Laboratory test * WBC diff count, Hb, creatinine, ALT, albumin, hsCRP, ESR cortisol, serotonin, DHEA-s, IGF-1, NK cell, Telomere length 3. Questionnaire: K-MMSE, SGDS-K, BEPSI-K, EQ-5D-5L 4. Physical\& muscular assessment * SPPB, Grip strength, Muscle tone, Bioimpedance analysis 5. Compliance 6. Adverse events
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
80
Patient should use massage chair, twice per day, for 30minutes
AsanMC
Seoul, South Korea
Serum cortisol level
Investigate serum cortisol level of baseline \& 24weeks between 2 groups.
Time frame: Change from baseline serum cortisol level at 24weeks
Cortisol/DHEA-s ratio
Investigate serum Cortisol/DHEA-s ratio level of baseline \& 24weeks between 2 groups.
Time frame: Change from Baseline cortisol/DHEA-s ratio level at 24weeks
Serum Serotonin level
Investigate serum serotonin level of baseline \& 24weeks between 2 groups.
Time frame: Change from Baseline serum serotonin level at 24weeks
Serum IGF-1 level
Investigate serum IGF-1 level of baseline \& 24weeks between 2 groups.
Time frame: Change from Baseline Serum IGF-1 level level at 24weeks
ESR
Investigate serum ESR level of baseline \& 24weeks between 2 groups.
Time frame: Change from Baseline ESR level at 24weeks
hsCRP
Investigate serum hsCRP level of baseline \& 24weeks between 2 groups.
Time frame: Change from Baseline hs CRP level at 24weeks
NK cell activity
Investigate serum NK cell activity of baseline \& 24weeks between 2 groups.
Time frame: Change from Baseline NK cell activity level at 24weeks
Telomere length
Investigate Telomere length of baseline \& 24weeks between 2 groups
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Time frame: Change from Baseline Telomere length level at 24weeks
Korean version Short form Geriatric Depression Scale(SGDS-K) score
15 item measure to assess the depression
Time frame: SGDS-K summed total score is changed lower at 24weeks from baseline
Korean version -Brief Encounter Psychosocial Instrument(BEPSI-K) score
5 item measure to assess the Stress
Time frame: BEPSI-K summed total score is changed lower at 24weeks from baseline
The 5-level EQ-5D version(EQ-5D-5L) score
6 item measure to assess the quality of life
Time frame: EQ-5D-5L summed total score is changed higher at 24weeks from baseline
Muscle tone score
6 item measure to assess Muscle tone of both trapezoid\& forearm \& thigh
Time frame: Individual site Muscle tone score is changed higher at 24weeks from baseline