The purpose of this study is to evaluate the safety and efficacy of BUCYE conditioning regimens in primary central nervous system lymphoma undergoing autologous hematopoietic stem cell transplantation.
The prognosis of patients with primary central nervous system lymphoma (PCNSL) is poor. Recent studies have demonstrated that autologous hematopoietic stem cell transplantation (auto-HSCT) could improve the prognosis of these patients. However, the optimal conditioning regimen of auto-HSCT remains unclear. In this study, the investigators evaluated the safety and efficacy of BUCYE conditioning regimens in PCNSL undergoing auto-HSCT.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Busulfan was administered at 3.2 mg/kg/day on days-7 to -4.
Cyclophosphamide was administered at 60 mg/kg/day on days -3 to -2.
Etoposide was administered at 15 mg/kg/day on days -3 to -2.
Department of Hematology,Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
RECRUITINGOS
overall survival (OS)
Time frame: 2 year
DFS
disease-free survival (DFS)
Time frame: 2 year
relapse rate
relapse rate
Time frame: 2 year
TRM
transplant-related mortality (TRM)
Time frame: 2 year
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