PRP Intrauterine Infusion in Thawed Embryo Cycles

Tanta University102 enrolled

Overview

All patients prepared to thawed embryo transfer were classified into 2 groups one group will receive platelet rich plasma (PRP) infusion intrauterine and the other group will not receive platelet rich plasma (PRP) infusion

Patients candidates for Thawed embryo transfer with Repeated implantation failure were recruited from 3 centers and classified into 2 groups: Group I: Will receive platelet rich plasma (PRP) intrauterine infusion at day 11 Group II: Not receiving platelet rich plasma (PRP)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

102

Conditions

Evaluations

Interventions

Platelet rich plasma intrauterine infusionBIOLOGICAL

platelet rich plasma will be prepared, activated then infused by Intrauterine insemination catheter intrauterine at day 11

Normal salineBIOLOGICAL

Intrauterine infusion of normal saline at day 11

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients age 20-35 years * Patients with previous implantation failure * Patients with thin endometrium\<7 mm Exclusion Criteria: * Patients older than 40 years * Patients with fresh embryo transfer * Patients with abnormal uterine cavity septate, or bicornuate uterus * Patients with abnormal male factor or tubal factor * Patients with abnormal embryos grade B or C. * Patients with immunological disorders as thyroidits or systemic lupus or rheumatoid arthritis

Locations (1)

Ayman Shehata Dawood

Tanta, Egypt

Outcomes

Primary Outcomes

Endometrial thickness

The increase in endometrial thickness at day of ET

Time frame: 8 days

Pregnancy rate

Number of cases who got pregnant

Time frame: 15 days

Data from ClinicalTrials.gov

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