The Implication of Plasma ctDNA Methylation Haplotypes in Detecting Colorectal Cancer and Adenomas

Inclusion Criteria: Healthy Individuals: * Written informed consent must be obtained from healthy individuals to comply with the requirements of the study. * Healthy individuals who received colonoscopy. Patients with Colorectal Cancer or Adenomas: * Male or female ≥ 18 years of age on the day of signing informed consent. * Patients need to receive surgical resection or endoscopic resection. * Patients must have histologically confirmed stage I-IV colorectal cancer or adenomas * Patients must have a performance status of ≤1 on the ECOG Performance Scale. * Written informed consent must be obtained from patient or patient's legal representative and ability for patient to comply with the requirements of the study. Exclusion Criteria: * Patients received adjuvant treatment prior to the surgical resection. * Patients received blood transfusion two weeks before or during the surgical resection. * Patients with unresected advanced colorectal adenoma. * Patients who are positive for Human Immunodeficiency Virus (HIV), Hepatitis B or Hepatitis C. * Patients who are pregnant. * Patients who are alcoholic or drug abusers. * Patients with a history or current evidence of any condition or abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the Investigator.