A Study on the Effectiveness and Safety Evaluation of Combination Therapy With 1,927nm Thulium Laser and Fractional Microneedle Radiofrequency Equipment for Improvement of Skin Aging

Inclusion Criteria: 1. Healthy normal adults between 45 and 65 years of age 2. Subjects with moderate to severe wrinkles based on the Investigator's global assessment of lateral canthal line severity rating 3. Subjects who have voluntarily signed a written consent before 4. Subjects who can follow up during the trial 5. Subjects who have agreed to cease all dermatological treatment or treatment, including improvement of neck and face wrinkles, during this trial Exclusion Criteria: 1. If subjects do not want it or do not fill out a consent form 2. If subjects are allergic to local anesthetics (lidocaine) 3. Subjects who are Pregnant or lactating 4. Subjects who are deemed to be inadequate as subjects by the clinical investigator for the following patients or other pathologies 1) If the site of treatment has infectious or inflammatory skin disease 2) If the site of treatment has melasma or other pigmented dermatologic disease 3) If subjects have keloid disease, collagen, or elastic fiber disease 4) If subjects have chronic wasting disease (asthma, diabetes, etc.) 5) If subjects are taking anticoagulants and are at risk of bleeding 6) If subjects have an autoimmune disease 7) Subjects with psychiatric problems 8) Acute patients 5. Others in addition to the above items, if it is deemed difficult for clinical practice to be conducted at the discretion of the clinical trial manager (including illiteracy and other foreigners exclusion)