In the everyday clinical practice the incidence of minor complications is approximately 15-20% of the total number of third molar removals. Alveolitis (dry socket syndrome) may arise in 30-40% of the surgical tooth removals. Several preventive approaches are known, such as the use of iodoform gauze, zink-oxide eugenol paste, platelet rich fibrin (PRF), different medicine containing pastes, like antibiotics containing, non-steroid pain killer containing, steroid containing, or the application of chlorhexidine gel and solutions. In the case of a manifest alveolitis these methods can be used as well. The aims of this research are: i) to identify the important pathogens which play role in the development of alveolitis (microbiological methods), ii) to analyze the in vitro effectivity of the different antiseptic materials in case of infections (inhibitory zones) iii) to compare the effectivity of different alveolitis preventive methods in a prospective clinical study, iv) to compare the different treatment options in alveolitis in a prospective clinical study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
50
Patients get iodoform (1000 grams containing 350 grams of iodoform, 300 grams of glycerin and 350 grams of alcohol 96%) soaked gauze (steril selvedge gauze bandage 2 cm x 5 m in appropriate length) drainage during suture placements for a week.
Routine primary wound closure with single interrupted sutures (Surgilon 3-0 non-absorbable) only.
Extraction sockets are filled with 1% chlorhexidine gel (Curasept ADS310, Sager Pharma, Sager Dental Kft.,Budapest, Hungary) before suture (Surgilon 3-0 non-absorbable) placements.
Department of Oral and Maxillofacial Surgery, University of Pécs
Pécs, Hungary
RECRUITINGChange in minor postoperative complications (trismus)
Measuring postoperative trismus (maximal mouth opening - inter-incisal distance in millimeters).
Time frame: day of surgery, 3rd, 7th postoperative days
Change in minor postoperative complications (oedema)
measuring postoperative oedema (flexible ruler- lateral canthus-mandibular angle distance in millimeters and tragus-labial commissure distance in millimeters).
Time frame: day of surgery, 3rd, 7th postoperative days
Change in minor postoperative complications (pain)
Measuring level of pain in Visual Analog Scale (minimum score is 0 which represents no pain, maximum score is 10 which shows the worst pain) postoperatively
Time frame: 1st, 2nd, 3rd, 4th, 5th, 6th and 7th postoperative days
Change in necessity of postoperatively taken analgesics
Registering dose of active agent of taken analgesics in milligrams .
Time frame: 1st, 2nd, 3rd, 4th, 5th, 6th and 7th postoperative days
Change in necessity of postoperatively taken analgesics
Registering number of daily repeats of taken analgesics.
Time frame: 1st, 2nd, 3rd, 4th, 5th, 6th and 7th postoperative days
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