A Placebo-controlled Trial of Percutaneous Coronary Intervention for the Relief of Stable Angina

Inclusion Criteria: ORBITA-2 will enrol patients who meet all 3 of the following criteria: 1. Angina or angina-equivalent symptoms 2. Anatomical evidence of significant coronary stenosis in at least one vessel, either: a. Invasive diagnostic coronary angiogram indicating ≥ 70% stenosis b. CT coronary angiography indicating ≥ 90% stenosis 3. Evidence of ischaemia, arising from at least one of the following options: 1. Positive dobutamine stress echocardiography 2. Positive cardiac MRI perfusion scan 3. Positive nuclear medicine myocardial perfusion scan 4. Invasive pressure wire assessment suggestive of ischaemia, as judged by the interventional cardiologist, at the time of diagnostic angiogram or research angiogram Exclusion Criteria: 1. Age younger than 18 2. Age older than 85 3. Recent acute coronary event 4. Previous coronary artery bypass graft surgery 5. Significant left main stem coronary disease 6. Chronic total occlusion in the target vessel 7. Contraindication to percutaneous coronary intervention or drug-eluting stent implantation 8. Contraindication to antiplatelet therapy 9. Severe valvular disease 10. Severe LV systolic impairment 11. Severe respiratory disease 12. Life expectancy less than 2 years, pregnancy, unable to consent