Local Injection of Ozone Versus Methylprednisolone Acetate in Carpal Tunnel Syndrome of Scleroderma Patients

Assiut University50 enrolled

Overview

Carpal tunnel syndrome is a common peripheral entrapment neuropathy, this study aims to investigate if, and to what extent local ozone therapy could offer symptom improvement in scleroderma patients with Carpal tunnel syndrome

Carpal tunnel syndrome (CTS) is the most common compression syndrome the upper extremities. Its problem has a high prevalence ranged estimated prevalence of 3.8% in the general population, 3 and 7.8% in the working population. It occurs at any age, especially in individuals in their 40s to 60s, and the male: female ratio is reported to be 3:7. A lot of treatment modalities have been tried to improve the condition, starting from local anesthetic injection, steroid, and up to surgical decompression of the nerves. Scleroderma patients are a special group which usually sufferers from such problem

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Carpal Tunnel Syndrome Chronic Pain Scleroderma

Interventions

OzoneDRUG

After prepping and draping the area, intracarpal injection of ozone/oxygen mixture (20 ml, 25μg/ml) will be performed under sonographic guidance

methylprednisolone acetateDRUG

After prepping and draping the area, intracarpal injection of methylprednisolone acetate 40mg, and 40 mg lidocaine (20 ml, volume) will be performed under sonographic guidance

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients with scleroderma * complaining of carpal tunnel syndrome of 3-month duration or more * diagnosed axonal neuropathy using electrodiagnosis, nerve conduction study Exclusion Criteria: * patient refusal * infection at the site of intervention * previous injection in the recent 3 months * Coagulopathy

Locations (1)

Emad Zarief Kamel Said

Asyut, Egypt

Outcomes

Primary Outcomes

to assess pain alleviation through the visual analog scale (VAS)

visual analog scale of pain value of (0 cm) no pain , and value of (10 cm) worst pain

Time frame: 6 months

Secondary Outcomes

Changes in median nerve conduction parameters

distal motor latency

Time frame: 6 months

Data from ClinicalTrials.gov

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