Bioavailability of EPA + DHA Enriched Canned Tuna and Its Acute Effects

Inclusion Criteria: * Adult men or women * Age 18 - 59 years * Willing to maintain usual diet and physical activity patterns * Willing to comply with study protocol and procedures * Willing to provide written informed consent Exclusion Criteria: * Pregnant, breastfeeding or planning to become pregnant within the study period * Subjects with current or previous cardiovascular disease (ischemic cardiovascular disease, angina stable or unstable; myocardial infarction, stroke or symptomatic peripheral arteriosclerosis) * Subjects with liver or kidney diseases or cancer * Diabetes mellitus (fasting glycemia\> 126 mg / dL) * Uncontrolled hypertension (systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg) * Subjects with history of drug, alcohol or other substances abuse, or other factors limiting their ability to cooperate during the study * Subjetcs with gastrointestinal disorder or under prescription for medication affecting gastrointestinal function or absorption of nutrients * Known allergy (or sensitivity) to omega-3 fatty acids, fish (tuna), crustaceans, lactose or any meal ingredient * With antihypertensive therapy * Health condition that prevents compliance with study requirements * Subjects under prescription for medication for digestive symptoms such as anti-spasmodic, laxatives and anti-diarrheic drugs or other digestive auxiliaries * Subjects under prescription of anticoagulant drugs * Dietary patterns or supplement use that could interfere with study evaluations * Subjects not willing to avoid the consumption of fish oil or food supplements, including fatty acids, during the study (except as indicated in the study protocol) * Use of antibiotics in the last 4 weeks and laxatives in the last 2 weeks