This study aims to analyze the multi-omics results between eutopic endometrium, adenomyosis and endometriosis of patients diagnosed of adenomyosis with and without endometriosis. The multi-omics profiles include whole exome sequencing, analysis of transcriptomics and metabolomics. A comprehensive multi-omics will reveal the pathogenesis of adenomyosis.
Study Type
OBSERVATIONAL
Enrollment
200
A multi-omics analysis including whole exome sequencing, transcriptomics and metabolomics for eutopic and ectopic endometrium
Lei Li
Beijing, Beijing Municipality, China
RECRUITINGFrequencies of somatic driving mutations
The differences of distributions and frequencies of somatic driving mutations will be compared between eutopic endometrium and ectopic endometrium by whole exome sequencing.
Time frame: Two years
Frequencies of alteration of RNA expression
The alteration of RNA expression, including mRNA, miRNA, and lncRNA, will be compared between eutopic endometrium and ectopic endometrium by transcriptome sequencing.
Time frame: Two years
Frequencies of alteration of protein expression and signal pathway
The alteration of protein expression and signal pathway will be compared between eutopic endometrium and ectopic endometrium by metabolomic sequencing
Time frame: Two years
Progression-free survival
Progression-free survival between patients with differential expressed multi-omics will be compared.
Time frame: Five years
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