This study aims to analyze the multi-omics results between epithelial ovarian cancer (EOC) patient with different FIGO stages and pathological subtypes. The multi-omics profiles include whole exome sequencing, analysis of transcriptomics and metabolomics. A comprehensive multi-omics will reveal the invasiveness and tumorigenesis of EOC.
Study Type
OBSERVATIONAL
Enrollment
80
A multi-omics analysis including whole exome sequencing, transcriptomics and metabolomics.
Lei Li
Beijing, Beijing Municipality, China
RECRUITINGFrequencies of somatic driving mutations
The differences of frequencies of somatic driving mutations will be compared between patients of different FIGO stages and different pathological subtypes.
Time frame: Two years
Frequencies of alteration of RNA expression
The alteration of RNA expression, including mRNA, miRNA, and lncRNA, will be compared between patients of different FIGO stages and different pathological subtypes.
Time frame: Two years
Frequencies of alteration of protein expression and signal pathway
The alteration of patterns of protein expression and signal pathway will be compared between patients of different FIGO stages and different pathological subtypes.
Time frame: Two years
Progression-free survival
Progression-free survival between patients with differential expressed multi-omics will be compared.
Time frame: Five years
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