This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections. The multi-omics profiles include genome wide association study (GWAS), whole exome sequencing, analysis of transcriptomics and metabolomics. The HPV integration status is interpreted by GWAS. A comprehensive multi-omics will reveal the role of HPV integration in the molecular mechanism of tumorigenesis and prognosis of uterine cervical adenocarcinoma.
Study Type
OBSERVATIONAL
Enrollment
40
A multi-omics analysis including genome-wide association study, whole exome sequencing, transcriptomics and metabolomics.
Lei Li
Beijing, Beijing Municipality, China
RECRUITINGFrequencies of somatic driving mutations
The differences of frequencies of somatic driving mutations will be compared between patients with and without HPV integration.
Time frame: Two years
Frequencies of alteration of RNA expression
The alteration of patterns of RNA expression, including mRNA, miRNA, and lncRNA, will be compared between patients with and without HPV integration.
Time frame: Two years
Frequencies of alteration of protein expression and signal pathway
The alteration of patterns of protein expression and signal pathway will be compared between patients with and without HPV integration.
Time frame: Two years
Progression-free survival
Progression-free survival between patients with differential expressed multi-omics will be compared.
Time frame: Five years
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