Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance

Mayo Clinic71 enrolled

Overview

The investigators expect to find that different intensity and altitude exposure levels will show what kind of intermittent exposure protocol is more beneficial to athletes and healthy individuals that experience acute exposure to altitude during exercise. This may furthermore be related to acute altitude exposure for recreational exercise use as well.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Altitude Hypoxia

Interventions

Simulated altitudeOTHER

Participants will exercise in simulated altitude will range between 2100 feet and 16400 feet and will increase according to arm guidelines

Placebo simulated altitudeOTHER

Participants will exercise at sea level at similar percentage of intensities to the simulated altitude group.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * 18-70 years of age, * history of good health, * generally active to competitive athletes. Exclusion criteria: * History of cardiac or pulmonary disease, * not currently active, * unable to exercise or meet study requirements (e.g., number of sessions), * live at altitude (\>2,100m or 7,000ft).

Locations (1)

Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Outcomes

Primary Outcomes

Change in hemoglobin

Time frame: Baseline, 2-week, 4-week, 6-week, and 8-week

Change in hematocrit

Time frame: Baseline, 2-week, 4-week, 6-week, and 8-week

Change in erythropoietin

Time frame: Baseline, 2-week, 4-week, 6-week, and 8-week

Secondary Outcomes

Change in peak VO2

Change from maximal exercise test performed at sea level

Time frame: Baseline and 6- and 8-week

Change in cycling performance at altitude

change in aerobic/anaerobic cycling performance at altitude

Time frame: Baseline and 6- and 8-week

Data from ClinicalTrials.gov

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