Fertility Preservation is now considered as crucial for the well-being of women battling cancer. However, others indications have more recently emerged. Women with endometriosis may represent a suitable group since they are at risk for compromise ovarian reserve. Data on FP in endometriosis patients are rare: only small retrospective study, case-reports and opinion publications .Nowadays, there is no available data concerning real indications for PF on endometriosis patients (endometriomas, risk of surgery, deep endometriosis?), criteria for eligibility (ovarian reserve parameters, age), quality of oocytes and number of oocytes necessary to give at least one live birth. We propose a monocentric observational cohort study, evaluating the efficacy of oocytes cryopreservation as fertility preservation procedure, in young adult female subjects with endometriosis, to finally define the criteria of eligibility for PF procedures in case of endometriosis.
Monocentric observational cohort study, enrolling young patients with endometriosis, without birth project for the moment, and asking for fertility preservation, in order to preserve mature oocytes. Protocol of this study : * information and signatures of consent file ; * ovarian stimulation, oocytes retrieval and mature oocytes cryopreservation (one or more procedures) * questionnaires every year, describing quality of life in this context of endometriosis and evolution (treatment, surgery, ART, pregnancies) * data about number and rate of thawed oocytes after preservation, pregnancy rate and live birth rate with these oocytes.
Study Type
OBSERVATIONAL
Enrollment
100
Service de Gynécologie Obstétrique et Médecine de la Reproduction Hôpital TENON
Paris, Île-de-France Region, France
RECRUITINGcharacteristics of patients who will benefit from preservation fertility in case of endometriosis (age, parameters of ovarian reserve, endometriosis stage and lesions, previous treatment or surgeries, previous fertility treatment)
baseline data
Time frame: 5 years
rate of patients who will re-use their cryopreserved oocytes
follow up data
Time frame: 5 years
oocytes survival rate
follow up data
Time frame: 5 years
pregnancy rate
follow up data
Time frame: 5 years
birth rate
follow up data
Time frame: 5 years
live birth rate
follow up data
Time frame: 5 years
Quality of life, during and after preservation fertility procedure assessed by SF-36 questionnaire
Patients complete a SF-36 questionnaire
Time frame: 5 years
Events between fertility preservation and re-use or end of the study 1
Nature of surgical procedures for endometriosis during the year
Time frame: 5 years
Events between fertility preservation and re-use or end of the study 2
Number of surgical procedures for endometriosis during the year
Time frame: 5 years
Events between fertility preservation and re-use or end of the study 3
Pregnancy during the year (and type of pregnancy: abortion, clinical pregnancy, delivery)
Time frame: 5 years
Events between fertility preservation and re-use or end of the study 4
Duration of medical treatement for endometriosis during the year: number of months during the year
Time frame: 5 years
Events between fertility preservation and re-use or end of the study 5
Type of medical treatement for endometriosis during the year: class of molecule
Time frame: 5 years
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