Comparative Evaluation of the Effect of Prophylactic Intraligamentary Injection of Dexamethasone and Piroxicam on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis

Cairo University42 enrolled

Overview

the study is conducted to assess and compare the efficacy of local intraligamentary injection of glucocorticoids(dexamethasone) and NSAID(piroxicam) on reduction of postoperative pain in patients with symptomatic irreversible pulpitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Postoperative Pain

Interventions

Dexamethasone sodium phosphateDRUG

prophylactic intraligamentary supplemental injection of 0.4 ml of 8 mg/2 mL dexamethasone.

Piroxicam Injectable SolutionDRUG

prophylactic intraligamentary supplemental injection of 0.4 mL of 20 mg mL-1 piroxicam

Mepivacaine HCLDRUG

prophylactic intraligamentary supplemental injection 0.4 mL of Mepivacaine HCl 36 mg /1.8 ml + Levonordefrin HCl 0.108 mg/ 1.8 ml

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Systemically healthy patient (ASA I or II). 2. Mandibular Posterior teeth with: * Preoperative sharp pain. * Absence of widening in the periodontal ligament (PDL). * Vital response of pulp tissue to cold pulp tester (ethyl chloride spray). Exclusion Criteria: 1. Patients allergic to anesthetics, piroxicam (any other NSAIDs) or dexamethasone (other corticosteroids). 2. Pregnant or nursing females. 3. Patients having significant systemic disorder (ASA III or IV). 4. Hemostatic disorders or anti-coagulant therapy during the last month. 5. Consumption of opioid or non-opioid analgesics or corticosteroids during the last 12 hrs before treatment. 6. Retreatment cases.

Outcomes

Primary Outcomes

Post operative pain assessed with the Numerical Rating Pain Scale

Intensity of pain after endodontic treatment is recorded by the patient using a numerical rating scale(where 0= no pain ,1-3 =mild pain ,4-6= moderate pain and 7-9= severe pain )

Time frame: up to 48 hours after root canal treatment (At 4,6,12,24 and 48 hours after root canal treatment ).

Secondary Outcomes

number of analgesics taken by the patient

Number of analgesic tablets taken by the patient after endodontic treatment.

Time frame: Until 48 hours after endodontic treatment.

Central Contacts

Safwa Es. Abd Elglil, B.D.S. (Cairo University)

CONTACT

01001259618 safwaessam91@gmail.com

Data from ClinicalTrials.gov

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