HIV Self-Testing AND Uptake and Retention of PrEP Among Older Adolescent MSM and TGW

Thai Red Cross AIDS Research Centre600 enrolled

Overview

This will be a prospective study that will enroll up to 600 older adolescent MSM and TGW from community-based clinics in Bangkok, Chonburi, Chiang Mai, and Songkhla.

All eligible participants will be followed up at month 3, 6, 9, and 12; month 6 and 12 will be mandatory clinic visits, while month 3 and 9 will be either clinic or a virtual visits. For participants accepting PrEP, additional follow-up visit at month 1, 2, 4, and 5 will be appointed; all visits will be either clinic or virtual visits. Study Sites The study will take place at the following community-based clinics: 1. SWING DIC, Bangkok, Thailand 2. RSAT DIC, Bangkok, Thailand 3. SWING DIC, Chonburi, Thailand 4. Sister DIC, Chonburi, Thailand 5. Caremat DIC, Chiang Mai, Thailand 6. MPlus DIC, Chiang Mai, Thailand 7. RSAT DIC, Songkhla, Thailand

Study Type

OBSERVATIONAL

Enrollment

600

Conditions

Men or Transgender Women Who Have Sex With Men

Eligibility

Sex: MALEMin age: 15 YearsMax age: 19 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Thai nationality 2. Age 15-19 years old 3. Men or transgender women who have sex with men 4. HIV-negative at the time of screening 5. Have at least one of the following risks for HIV acquisition in the past 6 months: 1. Any unprotected receptive anal sex with a male partner 2. More than 5 male partners, regardless of condom use and serostatus 3. Has had a bacterial sexually transmitted infection (STI) 4. Any injected drug use 6. Calculated creatinine clearance (CrCl) ≥ 75 mL/min, as estimated by the Cockcroft- Gault equation 7. Alanine aminotransferase (ALT) ≤ 2.5 x ULN 8. Have signed the informed consent form Exclusion Criteria: 1. HIV-positive 2. Hepatitis B infection as indicated by positive hepatitis B surface antigen (HBsAg) test at time of screening 3. Known allergy/sensitivity to tenofovir or emtricitabine

Locations (7)

1.Swing Dic,

Bangkok, Thailand

2. Rsat Dic,

Bangkok, Thailand

5. Caremat DIC,

Chiang Mai, Thailand

6. MPlus DIC,

Chiang Mai, Thailand

Outcomes

Primary Outcomes

Proportion of participants starting PrEP among those who use and do not use HIVST

Time frame: 3 years

Proportion of participants taking PrEP retaining in care among those who use and do not use HIVST

Time frame: 3 years

Data from ClinicalTrials.gov

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