Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life

Near East University, Turkey60 enrolled

Overview

Pericoronitis is a painful inflammatory condition which is well known for its negative impact on quality of life of those affected. The aim of this study was to test two hypotheses: (1) that topical application of Benzydamine is as effective as oral Diclofenac or Flurbiprofen in improving pain and quality of life of patients with pericoronitis and (2) that there would be no difference between the effects of the two oral NSAIDs on pain and quality of life of patients with pericoronitis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

Conditions

Pain Quality of Life

Interventions

DiclofenacDRUG

All patients were instructed to take one capsule orally every 8 h and apply the spray (4 puffs to the pericoronitis area) every 4 h for 7 days, commencing immediately after the clinical examination.

FlurbiprofenDRUG

All patients were instructed to take one capsule orally every 8 h and apply the spray (4 puffs to the pericoronitis area) every 4 h for 7 days, commencing immediately after the clinical examination.

BenzydamineDRUG

All patients were instructed to take one capsule orally every 8 h and apply the spray (4 puffs to the pericoronitis area) every 4 h for 7 days, commencing immediately after the clinical examination.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Young adults aged 18 years or over * Diagnosed with mild pericoronitis * Having semi-impacted mandibular third molar * Symptoms of pain and localized swelling Exclusion Criteria: * Smoking * History of allergy to diclofenac, flurbiprofen, benzydamine or other NSAIDs * Use of systemic antibiotics or analgesics within 3 days before admission * The patients who had symptoms of severe pericoronitis such as fever higher than 101°F, dysphagia, trismus or facial swelling.

Locations (1)

Abdullah AlAlwani

Mersin, Turkey (Türkiye)

Outcomes

Primary Outcomes

Oral Health-Related Quality of Life Scores Evaluated

For the pre- treatment period, the Oral Health-Related Quality of Life scores change was evaluated in the 1st day after the clinical examination and before the treatment with the help of the 5-point Likert-type scale where each item was scored from 1 (no trouble) to 5 (lots of trouble).

Time frame: Baseline

Oral Health-Related Quality of Life Scores Evaluated

For the post - treatment period, the Oral Health-Related Quality of Life scores change was evaluated with the help of the 5-point Likert-type scale where each item was scored from 1 (no trouble) to 5 (lots of trouble). Evaluated periods were 1, 2, 3, 5 and 7 days

Time frame: one week after drug prescribed

Secondary Outcomes

Pain Scores Evaluated

For the pre-treatment period, the pain scores change was evaluated in the 1st day after the clinical examination and before the treatment with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).

Time frame: Baseline

Pain Scores Evaluated

For the post-treatment period, the pain scores change was evaluated in the 1, 2, 3, 5 and 7days with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).

Time frame: one week after drug prescribed

Data from ClinicalTrials.gov

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