Allopurinol in Acute Coronary Syndrome

Inclusion Criteria: 1. the people who understand and would sign the informed consent voluntarily; 2. Aged 18 to 80 years old; 3. hospitalized patients diagnosed as acute coronary syndrome in the past 1 months; 1. hsCRP \> 2mg/L; 2. allopurinol allergy gene HLA-B5801 was negative. Exclusion Criteria: 1. history of coronary artery bypass grafting; 2. allergy to allopurinol or any excipient; 3. administration of allopurinol or other uric-acid-lowering drugs within 7 days before randomization; 4. abnormal liver function (ALT \>1.5 fold of the upper limit); 5. renal dysfunction (creatinine clearance rate \<45 ml/min); 6. thrombocytopenia (PLT\<100g/L); 7. gout patients; 8. uncontrolled infectious diseases in screening period; 9. Thyroid dysfunction, moderate to severe anemia (hemoglobin \< 90g/L), systemic lupus erythematosus, malignant hematopathy, leukopenia, asthma, inflammatory bowel disease and other immune diseases were found during the screening period; 10. Non-steroidal anti-inflammatory drugs, steroid hormone, immunomodulatory and chemotherapeutic drugs not included in the study protocol should be taken for a long time during the study period; 11. the history of surgery or interventional operation within 6 months before the screening period; 12. patients with mental disorders such as anxiety or depression; 13. pregnant women, lactating women or women of childbearing age who did not use effective contraceptive measures ; 14. patients who participated in other clinical trials 3 months before the screening period; 15. the researchers judged that patients were not suitable for this clinical trials.