HIV infection is associated to premature decline of serum testosterone. However, prevalence and biochemical characterization of hypogonadism in HIV-infected men are still to be well defined. HIV-infection is strongly associated to erectile dysfunction in men, but preliminary data suggest that it is poorly associated with serum testosterone in this context.
The aim of this study is to evaluate the gonadal function of young to middle aged HIV-infected men in order to characterize hypogonadism by assessing circulating total testosterone with either Liquid Chromatography tandem Mass Spectrometry (LC-MS/MS) or chemiluminescent immunoassay. Furthermore, secondary aim is to assess the erectile function through the use of validated questionnaires (International Index of Erectile Function (IIEF) 15 and 5).
Study Type
OBSERVATIONAL
Enrollment
315
No intervention is provided
Azienda Ospedaliero - Universitaria di Modena
Modena, Italy
Serum total testosterone
From blood sample - unit of measurement ng/dL
Time frame: Assessed only once at the moment of enrollment with liquid chromatography tandem mass spectrometry
Serum total testosterone
From blood sample - unit of measurement ng/dL
Time frame: Assessed only once at the moment of enrollment with chemiluminiscent immunoassay
Serum free testosterone
Calculated formula (Vermeulen equation)
Time frame: Calculated only once at the moment of enrollment
Score at IIEF questionnaire
Total score at erectile function domain of IIEF-15 questionnaire
Time frame: Assessed only once at the moment of enrollment
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