The Probiotic for Oral Health (PRO Health) Study

Inclusion Criteria: * Healthy adults; * Age 21-45 years of age; * BMI between 18-30; * No history of infectious disease; heart, metabolic, autoimmune endocrine, liver, or kidney diseases; GI related conditions such as malabsorption disease, Crohn's disease, colitis, inflammatory bowel disease; Type 1 or 2 diabetes mellitus, any type of cancer, heart disease; * Practices good oral hygiene according to the American Dental Association with brushing teeth between 1-2 times per day; * Willingness to only use the study toothpaste to brush or clean teeth and refrain from using any other oral-care products such as other toothpaste, mouthwash, rinses and breath-sprays during the five-week study period; * Willingness to limit consumption of raw onions or garlic and fermented foods such as sauerkraut, pickles, miso, and kimchi during the five-week study period; * Non-alcohol consumers or those who consume alcohol in moderation defined as having up to 1 drink per day for women and up to 2 drinks per day for men; * Willingness to avoid binge drinking during the study period defined by the Centers for Disease Control and Prevention as: This pattern of drinking usually corresponds to 5 or more drinks on a single occasion for men or 4 or more drinks on a single occasion for women, generally within about 2 hours; * Willingness to refrain from drinking any alcohol within 24 hours of each saliva sample collection; * Willingness to refrain from using illicit drugs during the five-week study; * Willingness to refrain from using tobacco (smoking or chewing) or smoking marijuana during the five-week study period; * Willingness to refrain from intake of probiotics, kombucha, or yogurt during the five-week study period; * Willingness to refrain from consuming more than 1 package of sugary candy and from chewing more than 1 package of chewing gum during the five-week study period; * Willingness to refrain from having any non-emergency, elective oral surgeries, dental procedures or dental teeth cleanings during the five-week study period. Exclusion Criteria: * Currently pregnant or plans to become pregnant several weeks prior to enrollment and during the five-week study period; * History of periodontal disease, or gingivitis; * Dental trauma or injury to the teeth and/or periodontium (gums, periodontal ligament, alveolar bone), and nearby soft tissues such as the lips, tongue within the past 4 weeks; * Any oral surgery or intensive procedures made to the oral cavity (such as fillings, wisdom tooth extraction, root canal, dental implants, etc.) within the past 4 weeks; * Routine dental cleaning within the past 4 weeks; * Use of probiotics, kombucha, or yogurt/kefir within the past 7 days of enrollment; * Use of probiotics containing S. salivarius within the past 8 weeks of enrollment; * Use of oral or IV antibiotics within the past 8 weeks of enrollment; * Consumption of more than one package of sugary candy (hard candy, gummy candy, mints, etc.) per day; * Use of more than one package of chewing gum (sugary or sugarless) per day; * Use of mouthwashes, mouth-rinses or breath-sprays more than three times per day; * Current tobacco (smoking or chewing) or E-cigarette users or individuals who quit using less than one year before enrolling in the study; * Frequent marijuana smoking or vaping, or use of other illicit drugs (must be no more than 12 times within the past year and no more than once per month); * Marijuana smoking or vaping or use of other illicit drugs within the past 4 weeks; * Excessive alcohol drinkers: For men, heavy drinking is typically defined as consuming 15 drinks or more per week. For women, heavy drinking is typically defined as consuming 8 drinks or more per week; * Individuals who live within the same household or who are in intimate relationships with current or past study participants (to avoid horizontal transfer of the oral microbiome); * Anyone the investigator feels isn't an applicable participant.