Inflammation and Cellular Immunity in Vaginal Tissue in Patients With Pelvic Organ Prolapse

Hillel Yaffe Medical Center20 enrolled

Overview

The aim of this study is to investigate the inflammatory and maturation processes of immature myeloid cells (IMC) in the vaginal tissue in women with advanced pelvic organ prolapse (POP) (stage III-IV) and in normal non-POP controls. We hypothesize that the processes contributing to POP may be related to immune response and changes in myeloid cell populations and the cytokine environment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pelvic Organ Prolapse

Interventions

HysterectomyPROCEDURE

Surgery performed on women with a variety of gynecological indications

ColporrhaphyPROCEDURE

Surgery performed on women with POP

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women with POP undergoing colporrhaphy * Women undergoing hysterectomy Exclusion Criteria: * Autoimmune and connective tissue disorders * Cancer in genital tract

Outcomes

Primary Outcomes

Immune response in POP

Tissue biopsy will analyzed for IMC and compared to control group

Time frame: Two weeks

Cytokine environment in POP

Tissue biopsy will analyzed for cytokine environment and compared to control group

Time frame: Two weeks

Central Contacts

Mariana Ordonez, MD

CONTACT

972-52-3243474 malo_mariana@hotmail.com

Data from ClinicalTrials.gov

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