This study involves Stereotactic Body Radiation Therapy (SBRT) followed by prostatectomy (removal of the prostate). SBRT is a relatively new radiation technique in which a few doses of radiation are delivered to small, well-defined tumors. It has been used effectively in other cancers like lung and liver. The radiation will be given for only 5 days. The purpose of this study is to compare the effects, good and/or bad, of different doses of SBRT given before prostatectomy.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
SBRT treatment
Measure of PSA (Prostate Specific Antigen)
Measure of PSA through treatment. PSA is expected to be undetectable (\<0.2 mg/ml) after prostatectomy and radiation therapy.
Time frame: Up to 12 months
Number of symptomatic adverse anastomotic events
Number of symptomatic anastomotic events related to pre-operative SBRT.
Time frame: Up to 12 months
Mean Catheterization Time
Average time of catheterization following prostatectomy
Time frame: Up to 4 weeks post surgery
Mean Hospital Stay
Average time of hospitalization after prostatectomy
Time frame: Up to 2 week post surgery
Quality of Life assessment
Quality of Life will be assessed using 2 questionnaires: International Prostate Symptom Score (IPSS) and Sexual Health Inventory for Men (SHIM). The IPSS is an eight question questionnaire of symptoms ranging from 0 "not at all" to 5 "always". The SHIM is a five question questionnaire ranging from 1 "almost never or never" to 5 "almost always or always" to determine erectile dysfunction.
Time frame: Baseline, at 2 weeks, 4 weeks, 2 months and every 3 months up to 12 months post surgery
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