To characterize the relationship of renal biomarkers (Creatinine, albumin, Cystatin C, NGAL, beta-trace protein, beta-2 microglobulin, and uromodulin) between each other and the variation over age, measured in serum and urine of healthy children. Unused residual blood and urine samples will be used for testing the renal Parameters.
Despite relevant research in renal biomarkers, there is currently no optimal marker available that reliably quantifies kidney function and indicates kidney injury in its early stages. The combination of two or more biomarkers might be a more promising approach than investigating a single parameter. The relationship of renal biomarkers (creatinine, albumin, Cystatin C, NGAL, beta-trace protein, beta-2 microglobulin, and uromodulin) between each other and the variation over age in infants and children (without chronic kidney disease) is investigated. The biomarkers in urine samples are explored to find less invasive means of quantifying renal health. Patients between the age of 0 and 12 years undergoing blood with or without urine sampling as part of their diagnostic workup are eligible for the study. Unused residual blood and urine samples will be used for testing the renal parameters.
Study Type
OBSERVATIONAL
Enrollment
158
relationship between the different biomarkers by linear regression analysis is assessed; influence of demographic variables (age, body weight, body surface area) is investigated by multivariate regression.
relationship between the different biomarkers by linear regression analysis is assessed; influence of demographic variables (age, body weight, body surface area) is investigated by multivariate regression.
University of Basel Children's Hospital
Basel, Switzerland
Serum concentration of creatinine (ymol/l)
blood test for renal biomarker
Time frame: single point in time at subject enrollment
Serum concentration of cystatin C (mg/l)
blood test for renal biomarker
Time frame: single point in time at subject enrollment
Serum concentration of Neutrophil gelatinase-associated lipocalin (ng/ml)
blood test for renal biomarker
Time frame: single point in time at subject enrollment
Serum concentration of beta-trace Protein (mg/l)
blood test for renal biomarker
Time frame: single point in time at subject enrollment
Serum concentration of beta-2 Microglobulin (mg/l)
blood test for renal biomarker
Time frame: single point in time at subject enrollment
Serum concentration of Uromodulin (ng/ml)
blood test for renal biomarker
Time frame: single point in time at subject enrollment
Urine concentration of creatinine (mmols/kg/24h)
Urine test for renal biomarker
Time frame: single point in time at subject enrollment
Urine concentration of cystatin C (mg/l)
Urine test for renal biomarker
Time frame: single point in time at subject enrollment
Urine concentration of Neutrophil gelatinase-associated lipocalin (yg/l)
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Urine test for renal biomarker
Time frame: single point in time at subject enrollment
Urine concentration of beta-trace Protein (mg/l)
Urine test for renal biomarker
Time frame: single point in time at subject enrollment
Urine concentration of beta-2 microglobulin (mg/l)
Urine test for renal biomarker
Time frame: single point in time at subject enrollment
Urine concentration of uromodulin (ng/ml)
Urine test for renal biomarker
Time frame: at time of enrollment
Urine concentration of Albumin (mg/l)
Urine test for renal biomarker
Time frame: at time of enrollment
Plasma protein binding of survival motor neuron (SMN) 2 splicing modifiers
blood test for spinal muscular atrophy
Time frame: single point in time at subject enrollment