Genetic an Functional Studies of Patient With Inflammatory Bowel Disease

University Hospital, Lille630 enrolled

Overview

The objective of this study is to study the response of macrophages, isolated from patients with ulcerative colitis (Crohn's disease) or Crohn's disease (CD), to 6 candidate enterogenous and their derivatives, depending on the genotype for associated polymorphisms. to the development of IBD

Study Type

OBSERVATIONAL

Enrollment

630

Conditions

Inflammatory Bowel Diseases

Eligibility

Sex: ALLMin age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient with definite crohn's disease or ulcerative colitis Exclusion Criteria: * patient receiving anti-TNF therapy during 14 days before inclusion.

Locations (1)

CHRU, Hôpital Claude Huriez

Lille, France

Outcomes

Primary Outcomes

Isolated macrophage response measured by PCR

identification of macrophage activation markers specific analysis of gene expression (by PCR in real time) and / or the production (ELISA) of proinflammatory molecules (IL-6, TNF-1 and IL-8), anti-inflammatory (IL-10) and immunomodulatory (IL4,PPAR -2, MOR)

Time frame: Baseline: one session

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.