This study aims to examine the effectiveness of the cognitive behavioral therapy in preventing the conversion of psychosis in a sample of individuals at-risk for psychosis.
Eligible subjects with informed consent provided will be randomly assigned to the cognitive behavioural therapy (CBT) group or psychoeducation group. Each group consists of 8 session spanning for 8 week.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
160
A total of 8 CBT sessions will be provided to the participants, each session lasts for approximately 1.5 hour.
A total of 8 psychoeducation sessions will be provided to the participants, each session lasts for approximately 1.5 hour.
University of Hong Kong
Hong Kong, Hong Kong
RECRUITINGFunctioning: Measured by Social and Occupational Functioning Assessment Scale (SOFAS)
Measured by Social and Occupational Functioning Assessment Scale (SOFAS). The SOFAS is an observer rating scale. Ratings should be based on subject's behavior during the last 1 month. The score ranges from 0-100. A higher score represents a better outcome.
Time frame: Changes from baseline to immediate, 6- and 12-month post-intervention
Functioning: Measured by Role Functioning Scale (RFS)
Measured by Role Functioning Scale (RFS). The RFS is comprised of four single rating scaled for evaluating the functioning of individuals in specified areas of everyday life. The four role functions assessed are:(1)Working: productivity, (2) Independent living and self care, (3) Immediate social network relationships, and (4) Extended social network relationship. The values on each of the four scales range from 1 (minimal level of role functioning), to 7 (hypothetically optimal level of role functioning). Each of the seven points on the scales is accompanied by a behaviorally defined description.
Time frame: Changes from baseline to immediate, 6- and 12-month post-intervention
Conversion of psychosis
Proportion of subject that convert from at-risk state to psychosis
Time frame: 12-month post-intervention
Positive psychotic symptoms
Measurement of positive symptoms using the Chinese version of the Psychotic Symptom Rating Scales (C-PSYRATS). It comprises of the auditory hallucinations (AHS) and delusions subscales (DS). The AHS has 11 questions and the DS consists of 6 questions, each question has the responses ranging from 0-4. The higher score represents more severe positive psychotic symptoms.
Time frame: Immediate, 6- and 12-month post-intervention
Beliefs about the auditory hallucination
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Measured by the Beliefs About Voices Questionnaire (BAVQ-R). The BAVQ-R has 35 questions, the 4 responses range from disagree, unsure, slightly agree to strongly agree. The higher score represents more convicted belief about the voices.
Time frame: Immediate, 6- and 12-month post-intervention
Depressive symptoms
Measured by the Calgary Depression Scale for Schizophrenia (CDSS). The scale consists of 9 questions, each has the response ranging from 0 to 3. The higher score presents more severe depressive symptoms.
Time frame: Immediate, 6- and 12-month post-intervention
Social anxiety :Measured by Liebowitz Social Anxiety Scale (LSAS)
Measured by Liebowitz Social Anxiety Scale (LSAS). The LSAS consists of 24 questions, the rater has to rate from 0-3 in Fear or Anxiety domain or Avoidance domain for each of the 24 questions. The higher score represents more severe social anxiety.
Time frame: Immediate, 6- and 12-month post-intervention