Comparison of Two Dosages of Heparin Before Extracorporeal Circulation

Astes150 enrolled

Overview

In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery.

In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery. The first dosage will be 300 IU per kilogram of REAL weight, the second dosage will be 300 IU per kilogram of IDEAL weight.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

150

Conditions

Extracorporeal Circulation; Complications

Interventions

ACT (Activated Clotting Time)DIAGNOSTIC_TEST

Measure of ACT in the two arms in order to determine if injection of heparin based on ideal weight is better or not than those one on real weight.

HeparinDRUG

300 IU of heparin

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients admitted for cardiac open chest surgery Exclusion Criteria: * Patient's refusal * Antithrombin III factor \< 75% * Patient under treatment by heparin IV

Locations (1)

Clinique Saint-Luc of Bouge

Namur, Belgium

Outcomes

Primary Outcomes

ACT performance

Measure of ACT to be \> 400 seconds to allow extracorporeal circulation, but also \< 700 seconds to avoid excessive bleeding.

Time frame: 1 minute

Data from ClinicalTrials.gov

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