A Registry Study on Genetics and Biomarkers of Acute Coronary Syndrome

ACS Case Inclusion Criteria: * Written informed consent has been provided. * Contact Order Form has been provided. * Aged 18 years or older. * Hospitalized within 48 hours of onset of symptoms. * Diagnosis of STEMI, NSTEMI or UA using the following definitions: 1.Criteria for STEMI diagnosis: 1. History of chest pain/discomfort and 2. Persistent ST-segment elevation (\> 30 min) of ≥ 0.1 mV in 2 or more contiguous ECG leads or presumed new left bundle branch block (LBBB) on admission and 3. Elevation of cardiac biomarkers (CK-MB, troponins): at least one value above the 99th percentile of the local laboratory upper reference limit. 2.Criteria for NSTEMI diagnosis: 1.History of chest pain/discomfort and 2.Lack of persistent ST-segment elevation, LBBB or intraventricular conduction disturbances and 3.Elevation of cardiac biomarkers (CK-MB, troponins): at least one value above the 99th percentile of the local laboratory upper reference limit. 3.Criteria for Unstable Angina diagnosis: 1. Symptoms of angina at rest or on minimal exercise and 2. At least 0.5mm ST deviation in at least 2 leads and 3. No increase in biomarkers of necrosis 4. OR objective evidence of ischaemia by non-invasive imaging OR significant coronary stenosis as determined by the treating physician at angiography if this is standard practice in study site. Case Exclusion Criteria: Patients will not be eligible to participate if any of the following exclusion criteria are present: * UA, STEMI and NSTEMI precipitated by or as a complication of surgery, trauma, or GI bleeding or post-PCI. * UA, STEMI and NSTEMI occurring in patients already hospitalized for other reasons. * Presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient (e.g. tourist, non-native speaker or does not understand the local language, psychiatric disturbances). * Presence of serious/severe co-morbidities in the opinion of the investigator which may limit short term (i.e. 6 month) life expectancy. * Current participation in a randomised interventional clinical trial. Control Inclusion Criteria: * Age and gender are matched with cases. * No Coronary Artery Disease was detected by Coronary CT examination. * Normal biochemical indicators.