The purpose of this study is evaluating the efficacy and safety of a topical herbal solution in males for the treatment of Androgenetic alopecia.
This study will be done on male subjects with Androgenetic alopecia(AGA). The patients will be selected by volunteers attending the Dermatology department of Sina Hospital, and eligible individuals will be selected among them. Subjects were randomized to use either Topical Herbal Solution or Topical Minoxidil 5% for 36 weeks. To our knowledge, this herbal solution for the first time covers all four major causes of AGA, including the 5α-reductase enzyme, androgen receptors, paracrine agents that affecting dermal papilla and hair cell apoptosis processes. Therefore it acts with the quadruple mechanism. The application of this new herbal solution for the treatment of AGA should be recommended.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
24
Use Topical Herbal Solution every day in scalp hair loss areas for 36 weeks.
Use Minoxidil 5% solution every day in scalp hair loss areas for 36 weeks.
Department of Dermatology, Sina Hospital
Tabriz, East Azerbaijan Province, Iran
Change in Hair Diameter
Change in hair diameter over time as compared to Baseline. Hair diameter measured via a digital micrometer.
Time frame: baseline, 12, 24, and 36 weeks
Patients Self - Assessment Questionnaire
Self-administered hair growth questionnaire, consisting of 4 questions in the patient's language on treatment efficacy and three questions on satisfaction with appearance. For differences between self-assessment questionnaires. This questionnaire following 5-point scale: 1 = very satisfied, 2 = satisfied, 3 = neutral (neither satisfied nor dissatisfied), 4 = dissatisfied, 5 = very dissatisfied. Higher scores indicated a worse outcome.
Time frame: through study completion
Adverse Events
Incidence of adverse events such as itching, redness, inflammation etc
Time frame: baseline, 12, 24, and 36 weeks
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