Renal Venous Flow and Cardiac Surgery-associated Acute Kidney Injury

University of Giessen200 enrolled

Overview

The prospective single-center study investigates the association between changes in Doppler-derived renal venous flow and cardiac surgery-associated acute kidney injury (CSA-AKI).

CSA-AKI is a common postoperative complication in patients undergoing open heart surgery, and is associated with increased mortality and morbidity. Venous congestion has been identified as the principal cause of cardiorenal decompensation in patients with heart failure but the relative contribution of congestion-driven renal function decline in CSA-AKI is not well studied. The prospective single-center study investigates whether serial Doppler-derived renal venous flow assessments could help identify subset of patients with cardiorenal syndrome and subclinical renal congestion at high risk of CSA-AKI.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Acute Kidney Injury Cardiorenal Syndrome

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Inclusion criteria: 1. Subjects older than 18 years 2. Subjects undergoing elective cardiac surgery (with or without cardiopulmonary bypass) 3. Subjects who signed informed consent forms Exclusion Criteria: 1. Patients requiring mechanical ventilation 2. Patients with mechanical circulatory assist devices or extracorporeal membrane oxygenation 3. Patients with stage 3 AKI with renal replacement therapy (RRT) or life- threatening volume overload treated with RRT 4. Stage ≥4 chronic kidney disease (CKD) stage 5. CKD requiring extracorporeal or peritoneal ultrafiltration for diuretic-resistant volume overload, 6) 6) Prediagnosed glomerulonephritis 6. Autosomal dominant polycystic kidney disease, postrenal obstruction, or solid organ transplantation 7. Anticipated life expectancy of \<12 months 8. Likelihood of receiving advanced therapy (mechanical circulatory assist device/cardiac transplant) 9. Pregnancy or possibility of pregnancy in the next 3 months 10. Rhabdomyolysis

Locations (1)

University Hospital Giessen and Marburg-Campus Giessen, Department of Cardiovascular Surgery & Department of Nephrology

Giessen, Hesse, Germany

Outcomes

Primary Outcomes

Association between perioperative changes in Doppler-derived renal venous venous flow and CSA-AKI

Doppler-derived renal venous flow

Time frame: preoperative, 24 hours postoperative, hospital discharge

Secondary Outcomes

Association of changes in postoperative renal venous flow profiles with renal recovery at hospital discharge

Doppler-derived renal venous flow

Time frame: Measured at Day 1 and Day 7 postoperative

Estimated GFR trajectory up to 3 months post-cardiac surgery relative to kidney

Estimated GFR

Time frame: Measured at 3 months post-surgery

Data from ClinicalTrials.gov

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