Safinamide for Multiple System Atrophy (MSA)

Inclusion Criteria: 1. Participant must be 30 to 80 years of age inclusive, at the time of signing the informed consent; 2. Participants who are diagnosed (with MRI confirmation) with possible or probable parkinsonian variant of Multiple System Atrophy less than 2 years ago; 3. Participants with an anticipated survival of at least 3 years in the opinion of the investigator; 4. Female not pregnant, not breastfeeding, and at least one of the following conditions applies: * Not a woman of childbearing potential OR * A woman of childbearing potential who agrees to follow the contraceptive guidance during the treatment period and for at least 30 days after the last dose of study intervention; 5. Capable of giving signed informed consent Exclusion Criteria: 1. History of neurosurgical procedure, including stereotactic surgery; 2. History of Deep Brain Stimulation (DBS); 3. History of bipolar disorder, severe depression, schizophrenia or other psychotic disorder; 4. History of drug and/or alcohol abuse within 12 months prior to screening as defined by the current edition of the Diagnostic and Statistical Manual of Mental Disorders; 5. History of dementia (DSM-V criteria); 6. Ophthalmologic history including any of the following conditions: albinism, uveitis, retinitis pigmentosa, retinal degeneration, active retinopathy, severe progressive diabetic retinopathy, inherited retinopathy or family history of hereditary retinal disease; 7. Active hepatitis B or C; 8. History of human immunodeficiency virus (HIV) infection; 9. Subjects not able to swallow oral medications; 10. Subjects with severe orthostatic symptoms; 11. Impaired ambulation, i.e. falling more than once per week, bedridden patients or confined to a wheelchair during the whole day; 12. Subjects with active malignant neoplasms; 13. Movement disorders other than MSA (e.g. Parkinson Disease, dementia with Lewy bodies, essential tremor, progressive supranuclear palsy, pharmacological or post-encephalic parkinsonism); 14. Any clinically significant or unstable medical or surgical condition that, in the opinion of the investigator, might preclude safe completion of the study or might affect the results of the study; 15. Not on a stable regime, for at least 4 weeks prior to the randomization (baseline visit), of 1. oral levodopa (including controlled release, immediate release or a combination of controlled release/immediate release), with or without benserazide/carbidopa, with or without addition of a catechol O-methyltransferase (COMT) inhibitor or 2. dopamine agonist, anticholinergic and/or amantadine. 16. Patients should not have received treatment with monoamine oxidase inhibitors in the 2 weeks prior to the randomization visit, nor treatment with levodopa infusion, pethidine, opiates, opioids, fluoxetine, fluvoxamine in the 4 weeks prior to the randomization visit; 17. Patients should not have received treatment with an oral or depot neuroleptic within 12 weeks prior to the randomization visit; 18. Use of any investigational drug within 30 days prior to screening or 5 half-lives, whichever is the longest; 19. Montreal Cognitive Assessment (MoCA) ≤ 20; 20. Laboratory assessments showing moderate or severe hepatic impairment (2x ULN); 21. Allergy/sensitivity or contraindications to the investigational medicinal products (IMPs) or their excipients, anticonvulsants, levodopa or other anti-parkinsonian drugs; 22. Any clinically significant condition which, in the opinion of the Investigator, would not be compatible with study participation or represent a risk for patients while in the study.