A Trial to Evaluate the Abuse Potential of 3 Doses of GRT6005 in Adult Non-dependent Recreational Opioid Users

Inclusion Criteria: 1. Informed consent signed. 2. Male and female, aged 18 years to 55 years, inclusive. 3. History of recreational opioid use (defined as non-therapeutic use at least 10 times in the participant's lifetime and at least once in the last 12 weeks prior to the Enrollment Visit). 4. Body mass index between 19 kilograms per square meter and 32 kilograms per square meter inclusive, with a body weight of not less than 50 kilograms at enrollment. 5. Participants must be in good health as determined by medical history, physical examination, 12-lead electrocardiogram (ECG), and vital signs (pulse rate, systolic blood pressure and diastolic blood pressure, respiratory rate, and oxygen saturation using pulse oximetry) at enrollment. 6. Adequate contraception is being used or women of non-childbearing potential may be enrolled if surgically sterile (i.e., after hysterectomy) or post-menopausal for at least 2 years (based on participant's report). * For women of childbearing potential: A medically acceptable and highly effective method of birth control is defined as any form of contraception with a low failure rate defined as less than 1 percent per year. For example: * Hormonal contraceptives for at least 8 weeks prior to the Enrollment Visit and at least until 4 weeks after the Final Examination. * An intra-uterine device. Additional barrier contraception should be used by the partner for the duration of the study, defined as from the time of the Enrollment Visit until 4 weeks after the Final Examination. A single barrier method alone is not acceptable. * For men: Participants must be willing to use medically acceptable and highly effective methods of birth control. Participants must be willing to use barrier contraception (condom) during sexual intercourse with females from the first administration of investigational medicinal product (IMP) until 4 weeks after the Final Examination. Participants must be willing to take care that their female sexual partner uses at least 1 additional method of contraception with a low failure rate defined as less than 1 percent per year (e.g., hormonal contraceptives, diaphragm) during this time frame. A single barrier method alone is not acceptable. Exclusion Criteria (at Enrollment): 1. Current substance dependence (except nicotine and caffeine dependence) as defined by the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV). 2. Unwillingness or inability to abstain from recreational drug use for the duration of the study. 3. Positive or missing alcohol breath test at enrollment. 4. Participants attempting to discontinue their recreational drug use or who had been in a drug rehabilitation program in the 12 months prior to enrollment. 5. Current consumption of more than 20 cigarettes per day or inability to abstain from smoking (or use of any nicotine-containing substance) for at least 26 hours. 6. Participation in another clinical study within 30 days prior to enrollment that resulted in the administration of at least 1 dose of IMP. 7. Diseases or conditions known to interfere with the absorption, distribution, metabolism, or excretion of drugs. 8. Prolongation of corrected QT interval (Fridericia) (QTcF) (after repeated assessment) at enrollment, i.e., above 450 milliseconds, or presence of additional risk factors for torsade de pointes (e.g., heart failure, hypokalemia), or use of concomitant medications that prolong QT interval. 9. History of orthostatic hypotension or other cardiovascular diseases. 10. Any clinically significant disease that in the investigator's opinion may affect efficacy or safety assessments or may compromise the participant's safety during study participation, e.g., significant pulmonary, gastrointestinal, cardiac, endocrine, metabolic, neurological, or psychiatric disorders. 11. Definite or suspected history of drug allergy or hypersensitivity to opioids or naloxone. 12. Use of forbidden medication within 2 weeks prior to enrollment into this study. 13. Any contraindication for naloxone or hydromorphone immediate-release (IR) administration. 14. Not able to abstain from consumption of: * Beverages or food containing caffeine (tea, coffee, cola, chocolate, etc.) or alcohol from 2 days prior to each Day 1 until discharge from the ward. * Beverages or food containing quinine (e.g., bitter lemon, tonic water) from 1 week before Day 1 of the Qualification Phase until the Final Examination. * Grapefruit juice (sweet or sour) or Seville oranges from 1 week before Day 1 of the Qualification Phase until the Final Examination. 15. Pregnant or breastfeeding women, or missing pregnancy test. 16. Blood loss of 500 milliliters or more within 4 weeks before enrollment in this study, including blood donation. Planned blood donations during the study and up to 12 weeks after the Final Examination. 17. History of seizure disorder and/or epilepsy or any condition associated with a significant risk for seizure disorder or epilepsy at the Enrollment Visit at the discretion of the investigator. 18. Known or suspected of not being able to comply with the study protocol. 19. Not able to communicate meaningfully with the investigator or study site staff. 20. Employee of the investigator or study site, with direct involvement in the proposed study or other studies under the direction of that investigator or study site, as well as family members of the employees or the investigator. Exclusion criteria (for Day 1) (Qualification Phase): 1. Positive naloxone challenge on Day -1 of the Qualification Phase. 2. Use of forbidden medication since the Enrollment Visit 3. Positive or missing urine pregnancy test. 4. Positive or missing alcohol breath test. 5. Positive or missing urine drug of abuse screen result, except for cannabinoids (tetrahydrocannabinol \[THC\]; due to slow release from adipose), which must be negative, stable, or decreasing. If THC is not negative, stable, or decreasing, inclusion will be at the discretion of the investigator, in consultation with the sponsor. 6. Positive or missing viral serology, i.e., human immunodeficiency virus Type 1 and Type 2 antibodies and antigen, hepatitis B surface antigens, antibodies to hepatitis B core antigen and immunoglobulin M antibody to hepatitis B core antigen, and hepatitis C virus antibodies, based on sample taken at the Enrollment Visit. 7. Any abnormal laboratory values or any clinically relevant out-of-range values for safety laboratory parameters (clinical chemistry, clotting, hematology, and urinalysis) based on sample taken at the Enrollment Visit, as judged by the investigator. 8. Blood donation or acute loss of blood (more than 100 milliliters) since the enrollment excluding blood samples required by the protocol. 9. Any relevant deterioration in the health of the participant that could alter the benefit/risk assessment for the participant, including adverse events, laboratory parameters, vital signs, or other safety parameters (e.g., ECGs). 10. Failure to comply with study requirements, e.g., intake of forbidden medications, consumption of alcohol, etc., considered by the investigator to affect participant safety or interfere with the integrity of the study. 11. Uncooperative participants or participants who refused to continue in the study. 12. Withdrawal of informed consent. 13. Any contraindication for naloxone or hydromorphone IR administration. Discontinuation criteria for Day 1 (Treatment Phase): 1. Failure to successfully fulfill any of the following criteria based on the qualification period prior to the first treatment period (Treatment Period 1, Day -1): * Peak scores (Emax) in response to hydromorphone greater than that of placebo on (at this moment) Drug Liking VAS (difference of at least 15 points). * Acceptable responses to placebo and hydromorphone on visual analog scale (VAS) for (at this moment) Drug Liking, High, Good Effects, Overall Drug Liking, Take Drug Again, and Feeling Sick, as judged by the investigator or designee and sponsor. * The ability to tolerate hydromorphone, as judged by the investigator based on available safety data (e.g., respiratory rate greater than or equal to 8 breaths per minute and no vomiting). * General behavior suggestive that they could successfully complete the study, as judged by the investigator. 2. Positive or missing urine pregnancy test. 3. Positive or missing alcohol breath test. 4. If a participant tests positive for other drugs of abuse, the urine drug screen can be repeated and/or the participant rescheduled at the discretion of the investigator or designee, in consultation with the sponsor. 5. Blood donation or acute loss of blood (more than 100 milliliters) since the Enrollment Visit excluding blood samples required by the protocol. 6. Any relevant deterioration in the health of the participant that could alter the benefit/risk assessment for the participant, including adverse events, laboratory parameters, vital signs, or other safety parameters (e.g., ECG). 7. Failure to comply with study requirements, e.g., intake of forbidden medications, consumption of alcohol, etc., considered by the investigator to affect participant safety or interfere with the integrity of the study. 8. Uncooperative participants or participants who refused to continue in the study. 9. Withdrawal of informed consent. 10. Not able to use adequate contraception as defined in Inclusion Criterion 6. 11. Not able to abstain from consumption of: * Beverages or food containing quinine (e.g., bitter lemon, tonic water). * Grapefruit juice (sweet or sour) or Seville oranges. * Beverages or food containing caffeine (tea, coffee, cola, chocolate, etc.) or alcohol.