single institution cases series review of histological and clinical data
single institution cases series review of histological and clinical data Investigators will retrieve from the archives of the Rizzoli Institute all the cases with a histological diagnosis of Angiomatoid Fibrous Histiocytoma. In all cases with enough available material, immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material.
Study Type
OBSERVATIONAL
Enrollment
9
IRCC Rizzoli Orthopedic Institute
Bologna, Italy
selection and review of 9 cases of Angiomatoid Fibrous Histiocytoma
investigators will review all the medical records, radiological imaging, and histological slides of all cases to identify the best therapeutic approach.
Time frame: at baseline (Day0)
analysis of EWS-CREB1 and EWS-ATF1 mutation and ALK expression on tissue tumor material
In all cases immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material. EWS-CREB1 and EWS-ATF1 mutation and ALK expression will be analyzed with RT-PCR and/or FISH analysis.
Time frame: at baseline (Day0)
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