FlowTriever All-Comer Registry for Patient Safety and Hemodynamics

Inclusion Criteria: * Clinical signs and symptoms consistent with acute PE * Echo, CTPA or pulmonary angiographic evidence of proximal filling defect in at least one main or lobar pulmonary artery * Scheduled for PE treatment with the FlowTriever System per the Investigator's discretion\* * US only: Patients enrolled in the Conservative Therapy Sub-study are not required to meet this inclusion criteria but must instead be scheduled for primary anticoagulation therapy as the primary treatment strategy. Exclusion Criteria: * Unable to be anticoagulated with heparin or alternative * Diagnosis with a minor PE with a less than 0.9 RV/LV ratio * Known sensitivity to radiographic contrast agents that, in the Investigator's opinion, cannot be adequately pre-treated\* * Imaging evidence or other evidence that suggests, in the Investigator's opinion, the subject is not appropriate for mechanical thrombectomy intervention\* * Life expectancy \< 30 days, as determined by Investigator * Current participation in another investigational drug or device treatment study that, in the Investigator's opinion, would interfere with participation in this study * US Only Patients enrolled in the Conservative Therapy Sub-study are not required to meet these exclusion criteria