Comparison of Hyaluronic Acid and Platelet-rich Plasma Injections

Bezmialem Vakif University40 enrolled

Overview

This study aims to compare the effects of hyaluronic acid injection and platelet rich plasma injection in terms of pain, physical function and femoral cartilage thickness in short term treatment in patients with knee osteoarthritis.

Platelet-rich plasma and hyaluronic acid injections are both popular treatments and commonly used for treatment of knee osteoarthritis. Even though there are many studies investigating the effectiveness of these treatments, the results are mostly qualitative. Also there are a few studies comparing these two treatment modalities. In this study the investigators aim to compare these modalities both for self-reported data (pain, physical function) and objective measurement data (femoral cartilage thickness via ultrasonography). Patients with unilateral osteoarthritis/unilateral complaint will be included in the study. Unaffected side will be controls for each group.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Knee Osteoarthritis

Interventions

Hyaluronic acid injectionBIOLOGICAL

Hyaluronic acid 48 mg 2.0% in 2.4 ml solution

Platelet-rich plasma injectionBIOLOGICAL

Platelet-rich plasma injection 5ml

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subject is able to consent * Subject meets Osteoarthritis Research Society International (OARSI) criteria for knee osteoarthritis * Subject has radiographic Kellgren-Lawrence grade 2-3 osteoarthritis * Unilateral osteoarthritis/complaint Exclusion Criteria: * Past or actual knee infection * History of surgery, fracture on knee * Collagen tissue disease * Systemic inflammatory disease (rheumatoid arthritis, spondyloarthritis etc.) * Systemic diseases (diabetes, hematologic diseases, endocrinopathies, renal failure, liver failure) * Knee injection in past 6 months * Immunodeficiency * Pregnant/breastfeeding * Malignancy

Locations (1)

Bezmialem Vakif University

Istanbul, Fatih, Turkey (Türkiye)

Outcomes

Primary Outcomes

Change of numeric rating scale (rest, movement)

Self reported pain scored between 0 (minimum)-10 (maximum). Higher scores represent a worse outcome.

Time frame: 0, 1st, 6th, months

Change of Western Ontario and McMaster Universities Osteoarthritis Index score(WOMAC)

Self reported questionnaire investigating 24 daily living activities. Each item is scored 0-5 (0:none 5:worst). Yielding a total between 0-100. Higher scores represent a worse outcome.

Time frame: 0, 1st, 6th months

Change of femoral cartilage thickness via ultrasonography.

Transverse plane femoral cartilage thickness from three landmarks (from articular cartilage pothole,from midpoint of medial border and pothole of cartilage, from midpoint of lateral border and pothole of cartilage). Measured in millimeters. The sum of three points indicate a total thickness. A higher measurement indicates a thicker cartilage representing a better outcome.

Time frame: 0, 1st, 6th months

Data from ClinicalTrials.gov

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