This study evaluates the relationship between growth and stool microbiota in premature infants.
Preterm infants often require increased caloric intake to maintain appropriate growth while in the neonatal intensive care unit (NICU). While some infants will have a clear source of need for greater calories, it is often not obvious why others require increased available calories to maintain appropriate growth. Emerging evidence suggests that patterns of gut microbiota may play a role in infant and childhood growth. We hypothesize that differences in the microbial pattern in preterm infants is related to poor growth and need for increased caloric intake. This may ultimately represent a therapeutic target to improve the growth of preterm infants in the NICU. This study aims to describe the differences in microbiome which may vary with growth pattern.
Study Type
OBSERVATIONAL
Enrollment
118
Infants will be provided standard of care and given calories required to maintain appropriate growth per unit policies already in place.
Parkland Hopsital and Health System
Dallas, Texas, United States
quantitative rT-PCR of stool microbiome
alpha diversity of bacterial groups in normal growth vs. poor growth
Time frame: 8-10 weeks depending on length of stay in NICU
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