Two hundred and ninety pregnant women with gestational age less than 20 weeks will be recruited in this study. Selenium and iodine conditions, and risk of thyroid disease will be monitored until termination of pregnancy, with pregnancy outcomes recorded.
The study will recruit 290 pregnant women with gestational age less than 20 weeks. Iodine and selenium condition will be evaluated through dietary recall (on base of Chinese food ingredient information) and biochemical examinations (serum iodine concentrations, urinary iodine concentrations, serum selenium concentrations, etc). The nutritional status of iodine and selenium will be monitored and followed up for all the included subjects throughout the pregnancy. The information of thyroid function and level of anti-TPO and anti-TG will be collected. And all the complications (especially thyroid disease) in pregnancy will also be recorded. All pregnant women will be followed up until the termination of pregnancy, with pregnancy outcomes recorded.
Study Type
OBSERVATIONAL
Enrollment
290
This study is an observational study. No intervention will be administered for research purposes.
risk of thyroid disease
prevalence of thyroid disease (abnormal thyroid function; development of thyroid antibodies)
Time frame: From date of participant inclusion until the date of termination of pregnancy, assessed up to 8 months
pregnancy outcomes
prevalence of premature birth, stillbirth and abortion
Time frame: From date of participant inclusion until the date of termination of pregnancy, assessed up to 8 months
prevalence of other pregnant complications
prevalence of gestational diabetes mellitus, gestational hypertension, dyslipidemia, etc.
Time frame: From date of participant inclusion until the date of termination of pregnancy, assessed up to 8 months
prevalence of thyroid disease in neonates
prevalence of thyroid disease (abnormal thyroid function; development of thyroid antibodies，or findings of thyroid nodules) in neonates
Time frame: From date of birth to 4 weeks after birth
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