Breast cancer is the most common cancer in women across the world, accounting for 25.2% of cancer cases among females and 14.7% of cancer-related deaths among females worldwide. The survival rates are markedly lower in the developing countries compared to developed countries, as well as the age at diagnosis. Core management of breast cancer includes surgical removal of the tumor either by breast-conserving surgery (BCS) or mastectomy (removal of the whole breast). Choosing between these two procedures may be influenced by factors that have yet to be studied in Saudi Arabia. The investigators aimed to determine the prevalence of BCS and mastectomy and the factors that may influence the choice of procedure. This retrospective study was carried out by reviewing the records of female breast cancer patients who underwent BCS or mastectomy at King Abdulaziz University Hospital between 2009 to June 2017, excluding those with metastasis (distant spread of the cancer) or recurrence. Using frequencies for the rate, and multivariate tests, the investigators analyzed different demographic, clinicopathological, and radiological factors to detect correlations with procedure choice.
Study Type
OBSERVATIONAL
Enrollment
335
Removal of the whole breast
Removal of the cancerous tissue only
Faculty of Medicine
Jeddah, Mecca Region, Saudi Arabia
Prevalence of each of mastectomy and breast-conserving surgery
The percentage of of patients who underwent each surgery
Time frame: 2009-2017
The relationship between the choice of procedure and the patients' age (in years)
Statistical analysis using independent sample T-test and binary logistic regression
Time frame: 2009-2017
The relationship between the choice of procedure and the use of preoperative chemotherapy (also called "neoadjuvant chemotherapy")
Statistical analysis using Chi-square test and binary logistic regression
Time frame: 2009-2017
The relationship between the choice of procedure and the tumor's laterality (right versus left breast cancer)
Statistical analysis using Chi-square test and binary logistic regression
Time frame: 2009-2017
The relationship between the choice of procedure and the tumor's focality (whether it is composed of more than one mass)
Statistical analysis using Chi-square test and binary logistic regression
Time frame: 2009-2017
The relationship between the choice of procedure and the tumor's centricity (whether it involves more than one quadrant of the breast)
Statistical analysis using Chi-square test and binary logistic regression
Time frame: 2009-2017
The relationship between the choice of procedure and the tumor's size (in centimeters)
Statistical analysis using independent sample T-test and binary logistic regression
Time frame: 2009-2017
The relationship between the choice of procedure and the tumor's stage (using the 7th "American Joint Committee on Cancer"'s staging guidelines)
Statistical analysis using Chi-square test and binary logistic regression
Time frame: 2009-2017
The relationship between the choice of procedure and the tumor's histological grade (using the Nottingham Histologic Score system)
Statistical analysis using Chi-square test and binary logistic regression
Time frame: 2009-2017
The relationship between the choice of procedure and the tumor's receptor status (whether it is positive for estrogen, progesterone, and/or human epidermal growth factor receptor 2)
Statistical analysis using Chi-square test and binary logistic regression
Time frame: 2009-2017
The relationship between the choice of procedure and having preoperative magnetic resonance imaging of the breast and its findings
Statistical analysis using Chi-square test and binary logistic regression
Time frame: 2009-2017
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