Glucocorticoid-induced Tumour Necrosis Factor Receptor Related Protein (GITR) in Rheumatoid Arthritis

Overview

This study aimed to measure serum and synovial fluid (SF) levels of GITR in patients with recent onset RA before and after initiation of therapy

1. Technical design: Study design: a longitudinal observational cohort study. This study will be carried out on two groups: * Group (I): fifty early onset rheumatoid arthritis (RA) patients fulfilled the 2010 American college of rheumatology (ACR) - European league against rheumatism (EULAR) classification criteria for RA \[11\]. * Group (II): Twenty healthy individuals of matching age and sex as control group. Both groups will be recruited from the in-patients and out-patients' clinic of the Rheumatology, Rehabilitation\& Physical Medicine Department, Benha University Hospital. All patients will be evaluated at baseline at 6 months follow up using: (A) Clinical evaluation 1. Complete history taking. 2. Thorough clinical examination. 3. Disease activity using DAS28 \[12\] (B) Laboratory assessment: All patients will be subjected to the following measurements: 1. Erythrocyte sedimentation rate (ESR). 2. C reactive protein (CRP). 3. Rheumatoid factor (RF) 4. Anti-cyclic citrullinated peptide (Anti- CCP). 5. glucocorticoid-induced tumour necrosis factor receptor related protein (GITR) (D) Musculoskeletal ultrasound assessment: Ultrasound examinations will be performed for patients and control groups using a Logiq e equipped with a broadband 8- to 13-MHz linear transducer 2. Statistical analysis The collected data will be tabulated and analyzed using suitable statistical computer version.

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

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