The two most common consequences resulting from aspiration are chemical pneumonitis and bacterial aspiration pneumonia. Both entities present with comparable clinical signs and symptoms. In the absence of a reliable clinical or biological marker to differentiate between these two conditions, most patients with suspected aspiration are treated empirically with antibiotics. De-escalation of initial antibiotic treatment is encouraged based on the results of microbiological results, usually performed before starting antimicrobial treatment. However, in most hospitals, 48-72h are required to obtain the results of microbiological cultures, and to de-escalate empirical large spectrum antibiotic treatment. The use of the Unyvero®, a multiplex PCR-based testing system, for detection of respiratory bacterial pathogens would allow decreasing the percentage of patients with aspiration syndrome who will receive unappropriated antibiotic treatment at Day 3.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
266
A multiplex PCR-based testing, will be used in addition to standard microbiological culture of the tracheal aspirate to diagnose bacterial pneumonia after inhalation
Standard strategy will be based on with standard microbiological culture of the tracheal aspirate to diagnose bacterial pneumonia after inhalation
Chu Amiens Picardie
Amiens, France
Hôpital Roger Salengro, CHU
Lille, France
The percentage of patients who will benefit from an early stop of the probabilist antibiotic treatment
Time frame: 48 hours after antibiotic treatment initiation
the percentage of patients who will receive appropriate antibiotic treatment.
Time frame: at Day 28 and Day 90 after antibiotic treatment initiation
the percentage of patients who will receive targeted antibiotic treatment.
Time frame: at Day 28 and Day 90 after antibiotic treatment initiation
mechanical ventilation free days.
Time frame: at Day 28 and Day 90 after antibiotic treatment initiation
length of ICU stay.
Time frame: up to Day 90
ICU mortality.
Time frame: up to Day 90
antibiotic free days.
Time frame: up to Day 90
percentage of patients with colonization or infection related to multidrug-resistant bacteria (MDR)
Time frame: at Day 28 and Day 90 after antibiotic treatment initiation
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