VF Mapping in Brugada and Early Repolarization Syndromes

Pacific Rim Electrophysiology Research Institute50 enrolled

Overview

To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with BrS and Early Repolarization.

The investigators will study symptomatic BrS and ERs syndrome (N=25) and asymptomatic patients (N=25) age between 16-70 years old to determine values and limitations of non-invasive mapping using electrocardiographic imaging (ECGI) in identifying VF substrates as target sites for catheter ablations in patients with Brugada (BrS) and Early repolarization syndromes (ERS) and also determine the mechanisms of VF in BrS and ERs syndromes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Brugada Syndrome Early Repolarization Syndrome

Interventions

radiofrequency ablationOTHER

Symptomatic patients whose substrates were identified will undergo catheter ablation; asymptomatic patients will be followed without undergoing catheter ablation.

Eligibility

Sex: ALLMin age: 16 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients presenting with the type1 BrS ECG or ER ECG signature pattern, with/without a sodium channel blocker. Patients with the following one of these symptoms or arrhythmias will be considered as symptomatic patients: 1) aborted cardiac arrest cases, 2) documented VF episodes, 3) agonal respiration during sleep with difficulty to arouse, 4) syncope of unknown origin, or 5) seizure suspected of arrhythmic origin.• Exclusion Criteria: Patients who refuse informed consent and to participate to the best ability in the study. Patients who have structural heart disease or concomitant medical illness.

Locations (2)

Bumrungrad International Hospital

Bangkok, Thailand

Pacific Rim Electrophysiology Research Institute Data Coordinating Center

Bangkok, Thailand

Outcomes

Primary Outcomes

VF death

ventricular fibrillation

Time frame: 3 years

Data from ClinicalTrials.gov

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