There is a growing body of evidence suggesting low water intake and elevated levels of the hormone vasopressin exacerbate glucose regulation. This project will examine the physiological mechanism by which low water intake impairs glucose homeostasis. In the current proposal we aim to: 1) quantify the degree of glucose impairment as a response to elevated vasopressin due to low water intake and 2) identify the physiological mechanism by which elevated vasopressin, as a response to low water intake, impairs glucose regulation
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
for 5 days prior to each experiment subjects will undergo manipulation of their water intake.
amount of glucose metabolized M
amount of glucose metabolized during the euglycemic \& Hyperglycemic clamp
Time frame: 220-240 min & 340-360 min of the protocol
metabolic clearance rate for insulin
metabolic clearance rate for insulin during the euglycemic \& Hyperglycemic clamp
Time frame: 220-240 min & 340-360 min of the protocol
quantity of glucose metabolized per unit plasma insulin concentration
quantity of glucose metabolized per unit plasma insulin concentration during the euglycemic \& Hyperglycemic clamp
Time frame: 220-240 min & 340-360 min of the protocol
Rate of glucose appearance & disappearance
Rate of glucose appearance \& disappearance during the euglycemic \& Hyperglycemic clamp
Time frame: 220-240 min & 340-360 min of the protocol
Plasma copeptin
Plasma copeptin in response to water manipulation
Time frame: 0 min, 240 min & 360 min of the protocol
glucagon
glucagon in response to water manipulation
Time frame: 0 min, 240 min & 360 min of the protocol
Cortisol
Cortisol in response to water manipulation
Time frame: 0 min, 240 min & 360 min of the protocol
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