This study evaluates micro-vascular changes in patients with diabetes. Results of diseased retinas will be compared to healthy controls.
The prevalence of diabetes mellitus (DM) is increasing worldwide. Diabetic retinopathy is the most prevalent complication of DM and a leading cause of visual impairment due to closure of capillaries. High-resolution imaging techniques of the retina and its supplying vascular networks can allow novel insight to subtle changes that cannot be appreciated in standard fundus examination. In this study capillary changes of patients with different severity levels of diabetic retinopathy will be investigated with non-invasive imaging technology to better understand the process of disease progression. Imaging will be done with Optical Coherence tomography (OCT) angiography as well as spectral domain OCT and ultra wide-field imaging.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
175
Multiple scans of the retina will be recorded to evaluate microvascular changes.
Eye Care Center
Vancouver, Canada
RECRUITINGPerfusion density
The density of perfused capillaries (metric variable) measured with optical coherence tomography angiography (OCTA) will be compared between the different severity levels of diabetic retinopathy as well as to the control arm.
Time frame: 6 months
Areas of different perfusion density
Perfusion density of the capillary network will be measured at seven different areas and will be compared within the same patient
Time frame: 6 months
Foveal avascular zone (FAZ)
Size (area) of FAZ will be compared between the different severity levels of diabetic retinopathy as well as to the control arm.
Time frame: 6 months
Foveal avascular zone (FAZ)
The circularity of FAZ will be compared between the different severity levels of diabetic retinopathy as well as to the control arm.
Time frame: 6 months
Presence of predominantly peripheral lesions (PPL)
The presence of PPL (categorical variable yes/no) will be correlated with the perfusion density measured with OCTA
Time frame: 6 months
Retinal layer thickness
Retinal layer thickness measured with optical coherence tomography (OCT) will be correlated with the perfusion density measured with OCTA
Time frame: 6 months
Change in perfusion density in patients with moderate or severe non proliferative diabetic retinopathy (DR) or low risk proliferative DR over the follow up of one year
Patients with moderate or severe non proliferative diabetic retinopathy (DR) or low risk proliferative DR will be followed over one year. Perfusion density will be measured at each timepoint and followed over the year,
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Time frame: 18 months