Study of Postoperative Cognitive Decline in Aged Patients

Jia-feng Wang300 enrolled

Overview

postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1，SOD2，Osteopontin， Kallikrein-6，and Contactin-1 and postoperative cognitive decline is unknown. In this project ,investigators examine the relationship between 5 cytokines measured at there timepoints (preoperative \[PREOP\], postoperative day 1 \[POD1\] , and postoperative day 3\[POD2\]) and postoperative cognitive decline among older adults undergoing orthopedic surgery.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Cognitive Decline

Eligibility

Sex: ALLMin age: 65 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients who are more than 65 years old * patients who undergo orthopedic surgery(trauma ,especially fracture of lower limb) * patients with ASA physical status I-III * patients who have a consent Exclusion Criteria: * patients who are more than 85 years old * patients with ASA physical status \>III * patients who have neurological disorders, stroke or other affective central nervous system diseases * patients who have a history of serious psychiatric illness * patients with long-term use of psychoactive substances * patients who undergo multiple trauma and the presence of head injury

Locations (1)

Deartment of anesthesiology,changhai hospital

Shanghai, Shanghai Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Differences in cytokines levels between the two groups

Compare differences in cytokines levels between the two groups

Time frame: preoperation

Differences in cytokines levels between the two groups

Compare differences in cytokines levels between the two groups

Time frame: 24h after operation

Differences in cytokines levels between the two groups

Compare differences in cytokines levels between the two groups

Time frame: 72h after operation

Central Contacts

wenbin lu

CONTACT

86+21-31161841 13004162573@163.com

Data from ClinicalTrials.gov

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