Lentivirally Redirected CD123 Autologous T Cells in AML

Inclusion Criteria: 1. Male or female subjects 18 years of age or older 2. Subjects with active acute myeloid leukemia (AML) with no available curative treatment options using currently available therapies. Specifically: 1. AML that has not achieved a complete remission or morphologic leukemia free state by ELN criteria (Döhner et al., 2017 Blood, 129(4):424-447); partial remission or refractory disease (including primary refractory) are eligible. Or: 2. AML relapsed following allogeneic stem cell transplantation (including MDS evolved to AML post-allogeneic stem cell transplantation). Note: morphologic relapse is not required; persistent/recurrent disease-associated molecular, phenotypic or cytogenetic abnormalities (measurable residual disease, MRD) at any time after allogeneic HCT is eligible 3. Subjects with relapsed disease after prior transplant must meet one of the following: a. Subjects with relapsed disease after prior allogeneic HCT (myeloablative or non-myeloablative) will be eligible if they meet all other inclusion criteria and i. Have no residual donor cells (by STR analysis on 2 occasions separated by at least 1 month), OR: ii. Donor cells are present but there is no active GVHD (\>Gr II), subject does not require systemic immunosuppression and is more than 3 months from transplant, and at least 1 month off GVHD prophylaxis. b. Subjects with relapsed disease after prior autologous or syngeneic HCT will be eligible if they meet all other inclusion criteria and it has been more than 3 months from transplant. 4. Subjects must have a suitable stem cell donor available who may donate cells in the event the subject needs to undergo an allogeneic HCT. Donor may be matched or mismatched and must be found to be suitable according to the institution's standard criteria; donors must be fully cleared to proceed as the donor. 5. Satisfactory organ functions: 1. Creatinine ≤ 1.6 mg/dl 2. ALT/AST must be ≤5 x upper limit of normal unless related to disease 3. Direct bilirubin or total bilirubin \< 2.0mg/dl, unless subject has Gilbert's syndrome (≤3.0 mg/dL); 4. Left ventricular ejection fraction ≥ 40% as confirmed by ECHO/MUGA 6. ECOG Performance status 0-2. 7. Written informed consent is given. 8. No contraindications for leukapheresis. 9. Subjects of reproductive potential must agree to use acceptable birth control methods (as described in protocol Section 4.3). Exclusion Criteria: 1. Pregnant or lactating (nursing women) women. 2. Patients with relapsed AML with t(15:17). 3. HIV infection. 4. Active hepatitis B or hepatitis C infection. 5. Concurrent use of systemic steroids or immunosuppressant medications. Recent or current use of inhaled steroids or physiologic replacement with hydrocortisone is not exclusionary. For additional details regarding use of steroids while on study, please see Section 5.5. 6. Any uncontrolled active medical disorder that would preclude participation as outlined. 7. Subjects with signs or symptoms indicative of CNS involvement. A CNS evaluation should be performed as clinically appropriate to rule out CNS involvement. 8. Known history of allergy or hypersensitivity to study product excipients (human serum albumin, DMSO, and Dextran 40). 9. Class III/IV cardiovascular disability according to the New York Heart Association Classification (see Appendix 3). 10. Patients with a known history or prior diagnosis of optic neuritis or other immunologic or inflammatory disease affecting the central nervous system, and unrelated to leukemia or previous leukemia treatment. 11. Subjects with clinically apparent arrhythmia, or arrhythmias that are not stable on medical management, within 2 weeks of the Screening/Enrollment visit. 12. Patients with any prior history of myeloproliferative neoplasm. 13. Patients with the JAK2 V617F mutation by PCR or next generation sequencing.